October 2025, Volume 2, No. 10
Table of Contents

Letter from the Editors

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CathWorks is redefining what a medtech partnership can be through a deliberate, globally minded build-to-buy model aimed at transforming how coronary artery disease is diagnosed and treated. Anchored by its “skin-in-the-game” partnership with Medtronic and its innovative wire-free and drug-free FFRangio System, the company has used markets across the United States, Europe, and Japan as real-world validation engines. The result is a model that combines scientific proof, speedy innovation, scalability, and partnership discipline that could impact how startups position themselves for acquisition.

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SOMAVAC is tackling one of the most neglected aspects of breast cancer care: post-surgical fluid management. Under the leadership of CEO Elizabeth Hoff, the company is bringing modern, negative pressure technology to a space that’s seen little change in more than 50 years. With SOMAVAC’s discreet, active-suction system, patients are recovering faster, avoiding complications, and regaining their mobility and their dignity.

Need fresh inspiration for your medtech company as we navigate Q425? We’ve gathered insights from some of our LSI alumni thought leaders to help you stay ahead.

Celebrating recent leadership shifts and other announcements and accolades impacting our global LSI Alumni medtech community.

Select Medtech Industry Financings & Deals: September 2025, by Date Announced

The cardiac rhythm management (CRM) device market is entering a new phase of modest but stable growth. Valued at $21.4 billion in 2024, the global CRM device market is projected to reach $26.6 billion by 2029, increasing at a CAGR of 4.4% over the 2024–2029 forecast period. As demand increases across aging populations, particularly in high-growth regions like China, manufacturers are racing to deliver innovations in pacing and defibrillation that meet clinical needs while minimizing complications.

ENT endoscopy is entering a new phase of steady but diverse growth, with unit volumes outpacing procedure growth and a widening range of technologies reshaping the competitive landscape. While market leaders retain a stronghold, disruptive players and falling ASPs are influencing the pace and shape of expansion.

Top medtech startups going into 2025 Q4 based on aggregated interest from investors and subscribers across our Compass platform and proprietary insights from LSI Emerging Medtech Summits in the USA, Europe, and Asia.

Every week, LSI’s Market Intelligence team tracks the biggest headlines, deals, and data shaping the future of medtech. In September, strategic alliances, implantable sensors, and analyst-selected breakout innovators took center stage, revealing a market driven by convergence, clarity, and capital efficiency.

This forecast accompanies our Innovator Spotlights on LSI Alumni SOMAVAC and MALCOVA, two companies driving progress across the breast cancer care continuum.

This forecast accompanies our Market Dive: Surgical Endoscopic ENT Devices, which starts on page 25.

With its proprietary Narrow-Beam CT platform, MALCOVA is reinventing frontline breast cancer imaging to better serve women with dense breast tissue. Co-Founder and CBO Tara Ghazi, PhD, shares how the company is advancing care, redefining screening, and setting a new bar for diagnostic precision.

Our Investor’s Corner spotlights capital partners who continue to drive innovation across medtech. This month, you will see featured deals and data from Sanara Capital, Panakès Partners, Gilde Healthcare, and more.

Celebrating the accomplishments of a few of the many bright stars in our LSI presenting company and speaker alumni community.

This month, we’re showcasing technologies and organizations impacting our industry and patient lives.

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