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A-Med Systems, Inc.
Baxter International, Inc.
CardioVention, Inc.
Chase Medical, Inc.
Coalescent Surgical, Inc.
Cohesion Technologies, Inc.
Computer Motion, Inc.
CryoLife, Inc.
Edwards Lifesciences Corporation
Estech, Inc.
Fusion Medical Technologies, Inc.
Guidant Corporation
Haemacure Corporation
Intuitive Surgical, Inc.
Johnson & Johnson
Jostra AG (Jostra Bentley Corporation)
Medtronic, Inc.
Pall Corporation
SNIA Group SpA/Sorin Biomedica Group
St. Jude Medical, Inc.
Terumo Corporation (Terumo Cardiovascular Systems)
Ventrica, Inc.
Vista Medical Technologies, Inc.
EXECUTIVE SUMMARY
Procedure Trends
Total Revascularization Products Market
Traditional Cardiopulomonary Bypass Products
Mini Bypass and Intracardiac Pumps
Anastomosis Devices
Beating Heart Surgery Disposables
Vein Harvesting Products
Other Emerging Technologies
Cardiac Surgical Sealants
Transmyocardial Revascularization
Product Suppliers
Summary Exhibit 1: Coronary Revascularization, Procedure Trend by Type, 2001-2008
Summary Exhibit 2: Open-Heart Surgeries by Approach, Procedure Forecast, 2001-2008
Summary Exhibit 3: Surgical Revascularization Products, Market Forecast, 2001-2008
Summary Exhibit 4: Traditional Cardiopulmonary Bypass Products, Market Forecast, 2001-2008
Summary Exhibit 5: Mini Bypass Products and Intracardiac Pumps, Market Forecast, 2001-2008
Summary Exhibit 6: Anastomosis Devices, Market Forecast, 2001-2008
Summary Exhibit 7: Beating Heart Surgery Core Disposables, Market Forecast by Type, 2001-2008
Summary Exhibit 8: Minimally Invasive Vein Harvesting, Market Forecast, 2001-2008
Summary Exhibit 9: Other Emerging Technologies, Market Forecast, 2001-2008
Summary Exhibit 10: Cardiac Surgical Sealants, Market Forecast, 2001-2008
Summary Exhibit 11: Transmyocardial Revascularization, Procedure and Market Forecast, 2001-2008
Summary Exhibit 12: Leading Suppliers of Surgical Revascularization Products, 2002
1.0 OVERVIEW OF CARDIOVASCULAR DISORDERS
1.1 Components and Function
1.1.1 Heart
1.1.2 Cardiac Cycle
1.1.3 Blood Vessels
1.2 Disorders of Heart and Circulation
1.2.1 Hypertension
1.2.2 Coronary Artery Disease
1.2.3 Congestive Heart Failure
1.2.4 Cardiac Arrhythmias
1.2.5 Stroke
1.2.6 Rheumatic Heart Disease
1.2.7 Acquired Valve Disorders
1.2.8 Congenital Heart Defects
1.3 Cardiovascular Disease Diagnosis
1.3.1 Non-Imaging Techniques
1.3.2 Imaging Techniques
1.3.2.1 Radiographic Imaging
1.3.2.2 Echocardiography
1.3.2.3 Radionuclide Scanning
1.3.2.4 Magnetic Resonance Imaging
1.3.2.5 Coronary Angiography
1.3.2.6 Intravascular Ultrasound
1.3.2.7 Intracoronary Angioscopy
1.3.3 Emerging Diagnostic Modalities
1.3.3.1 In Vitro Cardiac Markers
1.3.3.2 Predictor Tests
1.3.3.3 Monoclonal Antibody-Based Imaging of Thrombosis
1.4 Treatment of Cardiovascular Disease
1.4.1 Medical Management
1.4.1.1 Traditional Medical Management
1.4.1.2 Lipid-Lowering Drugs
1.4.2 Surgical Intervention
1.4.2.1 Coronary Artery Bypass Surgery
1.4.2.2 Valve Surgery and Treatment of Congenital Heart Defects
1.4.2.3 Transmyocardial Revascularization
1.4.2.4 Surgical Management of Atrial Fibrillation
1.4.3 Transcatheter Therapies
1.4.3.1 Percutaneous Transluminal Coronary Angioplasty
1.4.3.2 Coronary Stenting
1.4.3.3 Laser Angioplasty
1.4.3.4 Atherectomy
1.4.3.5 Transcatheter Thrombectomy and Thrombolysis
1.4.3.6 Transcatheter Defect and Valve Repair
1.4.3.7 Percutaneous Transmyocardial Revascularization
1.4.3.8 Catheter Ablation of Arrhythmias
Exhibit 1-1: The Heart
Exhibit 1-2: Selected Data on Deaths and Heart Diseases, 2000
Exhibit 1-3: Estimated Costs of Cardiovascular Disease and Stroke, 2003
Exhibit 1-4: Overview of Major Heart and Circulatory Disorders
Exhibit 1-5: Comparison of Left and Right-Sided Heart Failure
Exhibit 1-6: Selected Types of Arrhythmia
Exhibit 1-7: Major Congenital Heart Defects
Exhibit 1-8: Techniques Used for Diagnosing Cardiovascular Disease
Exhibit 1-9: Principal Drugs Used in the Treatment of Cardiovascular Disease, 2003
Exhibit 1-10: Major Surgical Interventions for Cardiovascular Disease, 2003
Exhibit 1-11: Major Surgical Approaches Used to Perform Cardiothoracic Surgery
Exhibit 1-12: Transcatheter Interventions for Cardiovascular Disease, 2003
2.0 CONVENTIONAL (STOPPED HEART) OPEN HEART SURGERY
2.1 Cardiopulmonary Bypass
2.1.1 Extracorporeal Circuit
2.1.2 Complications
2.1.3 Products
2.1.3.1 Blood Pumps
2.1.3.1.1 Roller Pumps
2.1.3.1.2 Centrifugal Pumps
2.1.3.2 Oxygenators
2.1.3.2.1 Design and Function
2.1.3.2.2 Add On Features
2.1.3.2.3 New Materials
2.1.3.2.4 Products and Suppliers
2.1.3.3 Accessories
2.1.3.3.1 Blood Filters
2.1.3.3.2 Hemoconcentrators
2.1.3.3.3 Cannulae and Tubing
2.1.3.4 Product Trends
2.1.3.4.1 Cardio Medical Solutions
2.1.3.4.2 CardioVention
2.1.3.4.3 Chase Medical
2.1.3.4.4 COBE/Sorin
2.1.3.4.5 Embol-X
2.1.3.4.6 Estech
2.1.3.4.7 Guidant
2.1.3.4.8 Jostra Bentley
2.1.3.4.9 Medtronic
2.1.3.4.10 Novare Surgical Systems
2.1.3.4.11 Terumo
2.1.3.4.12 New Materials and Coatings
2.2 Blood Recovery and Salvage
2.2.1 Cardiotomy Suction
2.2.2 Blood Salvage
2.2.2.1 Autotransfusion Process
2.2.2.2 Products and Technology
2.3 Myocardial Protection
2.3.1 Cardioplegia Circuit
2.3.2 Access for Cardioplegia
2.3.3 Cold versus Warm Cardioplegia
2.3.4 Products and Technology
2.4 Procedure Forecasts
2.4.1 Coronary Artery Bypass Graft Surgery
2.4.2 Valve Procedures
2.4.3 Other Procedures
2.5 Product Markets and Supplier Shares
2.5.1 Traditional Products
2.5.1.1 Blood Pumps
2.5.1.2 Traditional Bypass Disposables
2.5.1.3 Supplier Shares
2.5.2 Emerging Bypass Disposables
2 5.2.1 Anastomosis Devices
2.5.2.2 Anastomosis Assist Devices
2.5.2.3 Embolic Protection Devices
2.5.2.4 Mini Bypass Systems
Exhibit 2-1: Product Requirements for Open Heart Surgery Supported by Cardiopulmonary Bypass
Exhibit 2-2: Schematic of Cardiopulmonary Bypass Circuit
Exhibit 2-3: Potential Complications Associated with Cardiopulmonary Bypass
Exhibit 2-4: Components of Extracorporeal Circuit
Exhibit 2-5: Comparison of Roller and Centrifugal Pumps
Exhibit 2-6: Selected Heart-Lung Machines, 2003
Exhibit 2-7: Images of Selected Heart-Lung Machines, 2003
Exhibit 2-8: Selected Centrifugal Pump Systems, 2003
Exhibit 2-9: Images of Selected Centrifugal Pump Systems, 2003
Exhibit 2-10: Comparison of Soft-Shell and Hard-Shell Venous Reservoirs
Exhibit 2-11: Selected Membrane Oxygenators, 2003
Exhibit 2-12: Images of Selected Membrane Oxygenators, 2003
Exhibit 2-13: Selected Filters Employed in Cardiopulmonary Bypass Circuit
Exhibit 2-14: Selected Emerging Technologies for Reducing Bypass Complications
Exhibit 2-15: Cardio Medical Solutions Baladi Inverter
Exhibit 2-16: CardioVention CORx System
Exhibit 2-17: Chase Medical Tr3iumph Soft Occlusion Aortic Cannula
Exhibit 2-18: Embol-X Aortic Filter System
Exhibit 2-19: Estech Remote Access Perfusion Catheter
Exhibit 2-20: Guidant Heartstring Proximal Seal System
Exhibit 2-21: Jostra Bentley MECC System
Exhibit 2-22: Medtronic Portable Bypass System (PBS)
Exhibit 2-23: Novare Surgical Systems’ Enclose Anastomotic Assist Device
Exhibit 2-24: Features of Selected Autotransfusion Systems, 2003
Exhibit 2-25: Major Indications for Open Heart Surgery
Exhibit 2-26: Factors Impacting Revascularization Procedures Through 2010
Exhibit 2-27: Trend in CABG Surgery by Approach, Procedure Forecasts, 2001-2008
Exhibit 2-28: Stopped Heart versus Beating Heart CABG Surgery, Procedure Forecast, 2001-2008
Exhibit 2-29: Total Cardiopulmonary Bypass Caseload, Procedure Forecast, 2001-2008
Exhibit 2-30: Total Cardiopulmonary Bypass Products, Market Forecast, 2001-2008
Exhibit 2-31: Blood Pumps, Market Forecast by Type, 2001-2008
Exhibit 2-32: Traditional CPB Disposables, Market Forecast by Type, 2001-2008
Exhibit 2-33: Cardiopulmonary Bypass Products, Supplier Shares, 2002
Exhibit 2-34: Emerging Bypass Disposables, Market Forecast, 2001-2008
Exhibit 2-35: CPB Anastomosis Devices, Market Forecast by Type, 2001-2008
Exhibit 2-36: CPB Anastomosis Assist Devices, Market Forecast, 2001-2008
Exhibit 2-37: Embolic Protection Devices, Market Forecast, 2001-2008
Exhibit 2-38: CPB Mini Bypass Circuits, Market Forecast, 2001-2008
3.0 MINIMALLY INVASIVE (BEATING HEART) CARDIAC SURGERY
3.1 Beating Heart Techniques
3.2 Products
3.2.1 Stabilization and Positioning Products
3.2.1.1 Abbey Surgical
3.2.1.2 Chase Medical
3.2.1.3 CoroNeo
3.2.1.4 DMC Medical Limited
3.2.1.5 Edwards Lifesciences
3.2.1.6 ESTECH
3.2.1.7 Geister Medizintechnik GmbH
3.2.1.8 Genzyme Biosurgery
3.2.1.9 Guidant
3.2.1.10 Johnson & Johnson Ethicon (CardioVations, Heartport)
3.2.1.11 Medcanica/POPCAB LLC
3.2.1.12 MediVas OPCAB
3.2.1.13 Medtronic
3.2.2 Anastomosis Devices
3.2.2.1 Design Criteria
3.2.2.2 Products
3.2.2.2.1 Abbott Laboratories
3.2.2.2.2 Aptus Medical
3.2.2.2.3 Cardica
3.2.2.2.4 Coalescent Surgical
3.2.2.2.5 Converge Medical
3.2.2.2.6 Cryolife
3.2.2.2.7 Johnson & Johnson Cardiovations
3.2.2.2.8 Jomed
3.2.2.2.9 Kensey Nash
3.2.2.2.10 Onux Medical
3.2.2.2.11 St. Jude Medical
3.2.2.2.12 Stanford University
3.2.2.2.13 SuturTek
3.2.2.2.14 U.S. Surgical Corporation
3.2.2.2.15 Utrecht University Medical Center
3.2.2.2.16 Vasconnect
3.2.2.2.17 Vascular Innovations
3.2.2.2.18 Ventrica
3.2.3 Anastomosis Assist Devices
3.2.3.1 Guidant
3.2.3.2 Novare Surgical Systems
3.2.4 Intrasurgical Cardiac Assist
3.2.4.1 A-Med Systems
3.2.4.2 HemoDynamic Systems Ltd.
3.2.4.3 Impella Cardiotechnik
3.2.4.4 Medtronic
3.2.5 Minimally Invasive Vein Harvesting
3.2.5.1 Graft Sources
3.2.5.1.1 Radial Artery Grafts
3.2.5.1.2 Gastroepiploic Artery Grafts
3.2.5.1.3 Internal Thoracic Artery Grafts
3.2.5.2 Minimally Invasive Harvesting Techniques
3.2.5.2.1 Harvesting Technique
3.2.5.2.2 Advantages and Limitations
3.2.5.2.3 Endoscopic versus Direction Vision Approaches
3.2.5.2.4 Products
3.2.6 Intraluminal Shunts
3.2.6.1 Design
3.2.6.2 Application
3.2.6.3 Advantages and Limitations
3.2.6.4 Clinical Experience
3.2.6.5 Products and Suppliers
3.3 Trend in Beating Heart Procedures
3.4 Markets Analysis
3.4.1 Cardiac Stabilizers, Positioners and Accessories
3.4.2 Anastomosis Devices
3.4.3 Anastomosis Assist Devices
3.4.4 Intracardiac Assist
3.4.5 Vein Harvesting Systems
Exhibit 3-1: Comparison of Beating Heart CABG Surgery Techniques, 2003
Exhibit 3-2: Selected Cardiac Stabilizers, Positioners and Retractor Systems, 2001
Exhibit 3-3: Abbey Surgical Angelini Articulated Retractor
Exhibit 3-4: Chase Medical TR3IPOD Stabilizer System
Exhibit 3-5: CoroNeo CorVasc Stabilizer and Retractor
Exhibit 3-6: DMC Medical Cardioview Positioner
Exhibit 3-7: Edwards Lifesciences PauZition Heart Positioner
Exhibit 3-8: ESTECH Universal Stabilizerwith STableSoft
Exhibit 3-9: Geister Medizintechnik Lectiang Stabilizer
Exhibit 3-10: Genzyme Immobilizer Cardiac Stabilizer
Exhibit 3-11: Guidant Beating Heart Products
Exhibit 3-12: CardioVations AXIS 360o and Flexsite Stabilization Systems
Exhibit 3-13: Medcanica POPCAB Stabilizer Patent Drawings
Exhibit 3-14: Medtronic Octopus 4 System
Exhibit 3-15: Medtronic Starfish NS Heart Positioner
Exhibit 3-16: Major Design Approaches for Automated Anatomosis Devices
Exhibit 3-17: Selected Automated Anastomosis Devices, 2003
Exhibit 3-18: Coalescent Surgical U-Clip Device
Exhibit 3-19: Deployment of Jomed SOLEM GraftConnector
Exhibit 3-20: Onux Medical Touche Suturing System
Exhibit 3-21: St. Jude Medical Symmetry Bypass System with Aortic Connector
Exhibit 3-22: Suturtek FastClose Device
Exhibit 3-23: U.S. Surgical VCS Clip
Exhibit 3-24: Ventrica Magnetic Vascular Positioner
Exhibit 3-25: Deployment of Ventrica MVP System
Exhibit 3-26: Selected Anastomosis Assist Devices, 2003
Exhibit 3-27: Guidant Heartstring Proximal Seal System
Exhibit 3-28: Novare Surgical Systems Enclose Anastomosis Assist Device
Exhibit 3-29: Selected Intracardiac Assist Devices, 2003
Exhibit 3-30: A-Med A-Syst and PARAFlow Right Heart Support Systems
Exhibit 3-31: Impella Cardiotechnik impella elect
Exhibit 3-32: Comparison of CABG Graft Sources
Exhibit 3-33: Advantages and Limitations of Minimally Invasive Vein Harvesting
Exhibit 3-34: Selected Minimally Invasive Vein Harvesting Systems, 2003
Exhibit 3-35: CardioVations' Clearglide Precision Bipolar Device
Exhibit 3-36: Genzyme Biosurgery SaphLITE System
Exhibit 3-37: Guidant VasoView System
Exhibit 3-38: U.S. Surgical GSI ENDOsaph Vein Harvest System
Exhibit 3-39: Advantages and Limitations of Intraluminal Shunting for Beating Heart CABG Surgery
Exhibit 3-40: Features of Selected Intracoronary and Intraluminal Shunts, 2003
Exhibit 3-41: Selected Intracoronary and Intraluminal Shunts, 2003
Exhibit 3-42: Minimally Invasive CABG Surgery, Procedure Forecast, 2001-2008
Exhibit 3-43: Minimally Invasive Cardiac Surgery Products, Market Forecast, 2001-2008
Exhibit 3-44: Stabilizers, Positioners and Accessories, Market Forecast, 2001-2008
Exhibit 3-45: Stabilizers, Positioners & Accessories, Supplier Shares, 2002
Exhibit 3-46: Beating Heart Anastomosis Devices, Market Forecast, 2001-2008
Exhibit 3-47: Beating Heart Anastomosis Assist Devices, Market Forecast, 2001-2008
Exhibit 3-48: Beating Heart Cardiac Assist Products, Market Forecast, 2001-2008
Exhibit 3-49: Minimally Invasive Vein Harvesting Systems, Market Forecast, 2001-2008
Exhibit 3-50: Minimally Invasive Vein Harvesting Systems, Supplier Shares, 2002
4.0 ADJUNCTIVE TECHNOLOGIES
4.1 Endoscopic CABG
4.1.1 Products and Suppliers
4.1.1.1 Computer Motion
4.1.1.1.1 Procedure Requirements
4.1.1.1.2 Clinical Experience
4.1.1.1.3 Regulatory Status and Marketing
4.1.1.1.4 Development Plans
4.1.1.2 Johnson & Johnson/CardioVations/Heartport
4.1.1.2.1 Products
4.1.1.2.2 Procedure
4.1.1.2.3 Clinical Experience
4.1.1.2.4 Development Plans
4.1.2 Clinical Challenges and Benefits
4.1.3 Product Requirements
4.1.4 Market Analysis
4.2 Cardiac Robotics
4.2.1 Background
4.2.2 Technology
4.2.2.1 Automated Mechanical Assist Devices
4.2.2.2 Telemanipulators
4.2.2.3 Autonomous Robots
4.2.3 Applications in Cardiac Surgery
4.2.4 Regulatory Issues
4.2.5 Reimbursement versus Benefits
4.2.6 Products
4.2.6.1 Armstrong Healthcare Limited
4.2.6.1.1 EndoAssist
4.2.6.1.2 PathFinder
4.2.6.2 endoVia
4.2.6.3 Computer Motion
4.2.6.3.1 AESOP
4.2.6.3.2 ZEUS Robotic Surgical System
4.2.6.4 Intuitive Surgical
4.2.6.5 Micro Dexterity Systems
4.2.6.5.1 Components
4.2.6.5.2 NeuroDex and MicroDex
4.2.6.6 University of California at Berkley
4.2.6.6.1 Workstation Features
4.2.6.6.2 Tactile Feedback Device
4.2.6.6.3 Development Plans
4.2.7 Procedure Trend
4.2.8 Market Analysis
4.3 Advanced Visualization Systems
4.3.1 Technology
4.3.2 Requirements for Success
4.3.3 Products and Suppliers
4.3.3.1 Estech Least Invasive Cardiac Surgery
4.3.3.2 Intuitive Surgical
4.3.3.3 Medisecur AG
4.3.3.4 Microvision Inc.
4.3.3.4.1 Medical Industry Alliances
4.3.3.4.2 Clinical Resources
4.3.3.4.3 Confocal 3-D Camera
4.3.3.5 Olympus Optical Company
4.3.3.6 Karl Storz Endoscopy
4.3.3.7 VisionSense
4.3.3.8 Vista Medical Technologies
4.3.3.8.1 3-D Endoscope
4.3.3.8.2 Series 8000 System
4.3.3.8.3 Other Visualization Systems
4.3.3.8.4 Strategic Alliances
4.3.3.9 VRex
4.3.4 Market Analysis
Exhibit 4-1: Computer Motion EndoStabilizer
Exhibit 4-2: Key Outcomes for Endo-ACAB Procedure
Exhibit 4-3: Port-Access International Registry Patient Characteristics
Exhibit 4-4: Mortality and Morbidity of Port-Access Cardiac Surgery
Exhibit 4-5: Endoscopic CABG Surgery, Procedure and Market Forecast, 2001-2008
Exhibit 4-6: Types of Surgical Robotics
Exhibit 4-7: Selected Robotic Systems with Potential Application to Cardiac Surgery, 2002
Exhibit 4-8: EndoAssist Mechanical Assist Device
Exhibit 4-9: Computer Motion ZEUS and AESOP Systems
Exhibit 4-10: Intuitive Surgical da Vinci System
Exhibit 4-11: Microdexterity RAMS Schematic and MicroDex Prototype
Exhibit 4-12: Robotic-Assisted Beating Heart Cardiac Surgery, Procedure Forecast, 2001-2008
Exhibit 4-13: Cardiac Robotic Systems, Market Forecast by Type, 2001-2008
Exhibit 4-14: Cardiac Robotic Systems, Supplier Shares, 2002
Exhibit 4-15: Methods of Achieving Three-Dimensional Endoscopic Visualization
Exhibit 4-16: Selected Current and Emerging Advanced Visualization Systems, 2003
Exhibit 4-17: Stand-Alone Advanced Visualization Systems, Market Forecast, 2001-2008
5.0 SURGICAL SEALANTS
5.1 Surgical Sealant Design Criteria
5.2 Types of Surgical Sealants
5.3 Fibrin Sealants
5.3.1 Mechanism of Action
5.3.2 Development History
5.3.3 Commercial versus Non-Commercial Products
5.3.4 Autologous Platelet Gels
5.3.4.1 Interpore Cross International
5.3.4.2 Harvest Technologies
5.3.4.3 PlasmaSeal
5.3.4.4 ThermoGenesis
5.3.4.5 Vivolution A/S
5.3.5 Allogenic Products
5.3.6 Viral Screening and Inactivation of Blood Products
5.3.6.1 New Risks
5.3.6.2 Viral Inactivation and Removal Methods
5.3.7 Commercial Fibrin Sealants/Surgical Hemostasis Products
5.3.7.1 American Red Cross
5.3.7.2 AuraZyme Pharmaceuticals
5.3.7.3 Aventis Behring
5.3.7.4 Baxter Hyland Immuno
5.3.7.5 Cohesion Technologies/Angiotech Pharmaceuticals
5.3.7.6 Fusion Medical Technologies/Baxter
5.3.7.7 Haemacure Corporation
5.4 Recombinant Surgical Hemostasis Products
5.4.1 Cell Culture Technology (FibroGen/ZymoGenetics)
5.4.2 Transgenic Technology
5.4.2.1 Pharming
5.4.2.2 PPL Therapeutics
5.5 Alternatives to Hemostatic Sealants
5.5.1 Berlin Heart AG
5.5.2 C. R. Bard
5.5.3 Closure Medical Corporation
5.5.4 Cohesion Technologies/Angiotech Pharmaceuticals
5.5.5 CryoLife
5.5.6 Genzyme Biosurgery/Focal
5.5.7 Surgical Sealants Inc
5.5.8 Tissuemed
5.6 Market Analysis
Exhibit 5-1: Design Criteria for Ideal Surgical Sealant
Exhibit 5-2: Comparison of Major Categories of Surgical Sealants
Exhibit 5-3: Selected Biological Hemostatis Sealant Products, 2003
Exhibit 5-4: Current and Emerging Viral Inactivation and Removal Technologies
Exhibit 5-5: Advantages and Limitations of Non-Hemostatic Sealants
Exhibit 5-6: Selected Alternatives to Hemostasis Products, 2003
Exhibit 5-7: Cardiac Surgical Sealants, Market Forecast by Type, 2001-2008
Exhibit 5-8: Cardiac Surgical Sealants, Supplier Shares, 2002
6.0 TRANSMYOCARDIAL REVASCULARIZATION
6.1 Clinical Background
6.2 TMR Technique
6.3 Clinical Results
6.3.1 Long-Term Results
6.3.2 Adjunctive Use with CABG
6.3.3 Patient Selection
6.4 Proposed Mechanisms of Action
6.4.1 Channel-Mediated Perfusion
6.4.2 Angiogenesis
6.4.3 Myocardial Denervation
6.4.4 Placebo Effect
6.5 Products and Suppliers
6.5.1 AngioTrax
6.5.2 Cardiodyne
6.5.3 CardioGenesis
6.5.4 Montreal Heart Institute
6.5.5 Okayama University
6.5.6 PhotoMedex
6.5.7 PLC Medical Systems
6.5.8 Spectranetics/U.S. Surgical
6.6 Market Analysis
6.6.1 Procedure Forecast
6.6.2 Market Forecast
6.6.3 Competitive Analysis
Exhibit 6-1: Standard Angina Classification
Exhibit 6-2: Characteristics of "No Option" Angina Patients
Exhibit 6-3: Comparison of TMR and PMR
Exhibit 6-4: Transmyocardial Revascularization: Potential Mechanisms of Action
Exhibit 6-5: Selected Transmyocardial Laser Revascularization Programs
Exhibit 6-6: The CardioGenesis TMR 2000 Holmium:YAG Laser TMR System
Exhibit 6-7: PLC Medical Systems' Heart Laser 2 TMR System
Exhibit 6-8: Transmyocardial Revascularization, Procedure Forecast, 2001-2008
Exhibit 6-9: Transmyocardial Revascularization, Market Forecast, 2001-2008
Exhibit 6-10: Transmyocardial Revascularization, Market Shares, 2002
7.0 COMPANY PROFILES
7.1 A-Med Systems, Inc.
7.2 Baxter International, Inc.
7.3 CardioVention, Inc.
7.4 Chase Medical, Inc.
7.5 Coalescent Surgical, Inc.
7.6 Cohesion Technologies, Inc.
7.7 Computer Motion, Inc.
7.8 CryoLife, Inc.
7.9 Edwards Lifesciences Corporation
7.10 Estech, Inc.
7.11 Fusion Medical Technologies, Inc.
7.12 Guidant Corporation
7.13 Haemacure Corporation
7.14 Intuitive Surgical, Inc.
7.15 Johnson & Johnson
7.16 Jostra AG (Jostra Bentley Corporation)
7.17 Medtronic, Inc.
7.18 Pall Corporation
7.19 SNIA Group SpA/Sorin Biomedica Group
7.20 St. Jude Medical, Inc.
7.21 Terumo Corporation (Terumo Cardiovascular Systems)
7.22 Ventrica, Inc.
7.23 Vista Medical Technologies, Inc.
APPENDIX: COMPANY LIST