After nearly two decades developing heart valve technologies, mechanical engineer Ramji Iyer, Founder and CEO of Laplace Interventional, turned his attention to what is often referred to as structural heart’s “last frontier”: the tricuspid valve. The clinical-stage company has developed a transcatheter tricuspid valve replacement platform designed to make the procedure easier, adaptable to a broad range of patient anatomies, and gentle on the surrounding heart.
Ramji Iyer has spent nearly 18 years in medtech, structural heart in particular, developing technologies across the aortic, mitral, and now tricuspid valves.
A mechanical engineer by training, he began his career at St. Jude Medical, where he worked on surgical valves, pediatric mechanical valves, and transcatheter aortic valve replacement (TAVR) devices. He later led R&D for a transcatheter mitral valve startup that was successfully acquired. He then founded Plymouth, MN-based Laplace Interventional in 2020, turning his attention to the tricuspid valve, which, according to him, felt like the natural next step.
“Transcatheter tricuspid valve technology is the last frontier among the different valve technologies,” says Iyer, Founder and CEO of Laplace, in a recent conversation with The Lens. “It has its own challenges, its own complexities, but that’s what makes it fun, to come up with a solution to a cardiovascular problem with a huge impact on a patient’s quality of life.”
For patients, severe tricuspid regurgitation can mean much more than an abnormal valve. As the valve loses its ability to prevent blood from leaking backward into the right atrium, patients can experience fatigue, shortness of breath, swelling, and reduced ability to exercise, with advanced disease potentially progressing to right-sided heart failure.
Iyer didn’t start Laplace with a finished device in mind. He started with what he believed the technology needed to address: the unmet clinical need.
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