Emerging Medical Technologies Report

Table of Contents

BRIEF TECHNOLOGY DESCRIPTIONS FOR COMPANIES COVERED  

• Ultrasound catheters for targeted thermal ablation of tumors 

• Implantable devices for the endovascular treatment of hemorrhagic stroke 

• Intravascular temperature management systems and catheters for cardiac and neuro intensive care patients 

• Artificial lung delivers O2 and removes CO2 through a catheter inserted into the vena cava 

• Next-generation non-vascular interventional pulmonary and gastrointestinal stenting technology 

• Devices delivering infrared light to reduce pain and accelerate tissue healing 

• D-ribose, a five-carbon carbohydrate that increases cellular energy, improving cardiovascular health and tissue function 

• Cell-based therapy products for the treatment of heart failure secondary to myocardial infarction 

• Electronic device that closes the gap between drugs and surgery in osteoarthritis of the knee 

• Arthroscopic surgical devices 

• MIST Therapy using non-contact ultrasound to stimulate healthy cells allowing chronic wounds to heal 

• P-15: a small peptide attachment factor for bone formation in orthopedics 

• Minimally invasive needle biosensor for in vivo glucose or lactate monitoring of intensive care patients 

• Non-invasive modality for the treatment of insulin resistance/diabetic neuropathy 

• Methods for eyebrow lifting, non-thermal loading of degradable matrices, and degradable implants 

• Immunodiagnostics of placental recombinant markers to screen the risk of preeclampsia, preterm delivery, and IUGR 

• Next-generation biomaterials using bioactive-ceramics technology platform 

• Aortic arch stent graft 

• Monitor for autonomic nervous system displaying sympathovagal balance in real-time for diabetes/ anesthesia/cardiology applications 

• Portable automated critical care neuro instruments using advanced digital signal processing technology 

• Interventional catheter system for the mechanical recanalization of arterial chronic total occlusions quickly and reliably 

• THERMOCEPS - a handheld, wireless device that stops bleeding during surgical procedures using focused, thermal coagulation 

• Molecular diagnostics based on patented, standardized, next-generation, multi-gene expression (StaRT-PCR) products and high margin services 

• Automated, continual blood glucose monitoring for critically ill patients 

• Real-time, CT-guided, robotically controlled needle drivers for minimally invasive cancer therapy 

• Noninvasive, site-specific drug delivery technology to deliver compounds to the posterior segments of the eye 

• Prevention of scarring caused by disease, medical intervention, or trauma via a beta emitting biopolymer 

• A wireless, early detection and auto-alerting heart monitor system for outpatient and homecare markets 

• Trabectome, an FDA-cleared, minimally invasive medical device technology for the treatment of open angel glaucoma 

• Helical stent providing enhanced abilities and flexibilities in drug delivery, scaffolding, and embolic protection 

• Liposomal formulation of recombinant IL-2 for use as chemotherapy or cancer vaccine adjuvant 

• Bioresorbable polymer implants for use in a variety of orthopedics and spine surgical applications 

• CardioPath System that prevents embolic events by removing plaque and thrombus found in diseased arteries 

• BioSilicon, nano-structured porous silicon for applications in drug delivery, diagnostics, tissue engineering, and orthopedics 

• Conservative Motion Preservation technology including minimally invasive facet joint replacement 

• Catheters designed to diagnose, terminate, and treat cardiac arrhythmia during EP and ablation procedures 

• Artificial total intervertebral disc capable of normal physiological movement and weight loading 

• A wireless personal emergency alert system that integrates with, and enhances, existing implanted medical devices 

• A smart, communicating cigarette case, online support, and daily e-mails delivering an effective stop-smoking method 

• Minimally invasive disc replacement for chronic back pain 

• Surgical instruments employing thermal welding technology to seal and cut tissue 

• Endoscopy systems allowing physicians to see very small, early-stage cancer and subtle pre-cancerous lesions 

• Rapid, point-of-care in vitro diagnostics 

• AccessAED - portable, compact easy-to-use automated external defibrillators with full energy delivery and complete resuscitation solutions 

• Phase II drug/device combo product for bone regeneration in orthopedic and perio/oral surgery 

• Non-incisional female sterilization 

• Non-irritating dry electrodes now enabling long-term cardiac monitoring 

• Noninvasive ultrasound-based tissue analysis services for early detection of malignant tumors 

• Site-specific biological and drug delivery 

• Posterior dynamic stabilization device designed to support an injured or degenerated spine without eliminating motion 

• AepEX auditory evoked potential depth of anesthesia monitor and aepEX-Fusion servo-controlled anesthesia delivery system 

• Magnesium-based compound that will attach bone to bone and ligaments and tendons to bone 

• Cath lab solution providing rapid onset of circulatory support in patients with acute heart failure 

• Direct, real-time vision through flowing blood to guide therapy inside the heart and vessels 

• Micro-porous ceramic wound treatment device that creates optimal conditions for normal wound healing 

• Endovenous ablation system for varicose veins with 1320 nm CoolTouch laser 

• Impedance Cardiovelocimetry non-invasively measures/ monitors mechanical heart function and disease utilizing a disposable brachial cuff 

• ERBLAN MIS Surgical Devices allow safe entry into virtually any actual or potential anatomical space 

• Continuous, non-invasive glucose monitor for tight glycemic control at the hospital and at home 

• Augmented reality simulators that train surgeons in the skills required for minimally invasive surgery 

• Non-blood contacting, active implantable direct cardiac compression device for the treatment of CHF 

• Continuous blood gas monitoring and cardiac output measurement for the intensive care unit 

• Point-of-care platform technology (CRP & Cyst C) for assessing risk of cardiovascular disease and renal dysfunction 

• Nanotechnology-based cancer therapy with contactless activation of tumor-specific nano-particles, adaptable to all solid tumors 

• Precise miniature robotic technology for spine, knee, orthopedic, and neurosurgery minimally invasive procedures - SmartAssist 

• Virtual Bone Biopsy MRI scanner add-on, allowing noninvasive imaging of bone microstructure for osteoporosis monitoring 

• Implantable blood pump with magnetic levitation technology for patients suffering from heart failure 

• MRI-compatible, precision- guided laser therapy for the treatment of brain tumors 

• Nanomagnetic particles enabling controlled drug delivery and elution for drug targeting and medical device applications 

• Technology for imaging peripheral nerves in regional anesthesiology, pain management, and other markets 

• Catheter-based sealing of heart defects associated with stroke, migraine headaches, and other brain attacks 

• NovoSci Ready System 

• Implantable encapsulated-cell technology for delivery of biological therapeutics to the nervous system 

• Disposable balloon cervical dilator for improved uterine access that decreases pain, avoids tearing and perforations 

• First noninvasive, transcutaneous sensor array that continuously monitors peripheral circulation and/or core body temperature 

• Magneto-Optical Enantiomeric Detection (MOPED) for real-time, non-contact analysis of chiral pharmaceuticals 

• Tumor ablation by external activation of tiny spheres delivered systemically with antibodies 

• Real-time disposable stereotactic navigation devices for biopsy/targeted therapy compatible with CT, fluoroscopy, and MRI 

• Three-dimensional surgical visualization technologies and expanding portfolio for digital surgical environment and digital healthcare network 

• Second-generation, viscoelastic artificial disc restoring native function to the spine 

• BioDisc, a nucleus replacement product based on an injectable, flexible, and durable protein hydrogel technology 

• Dascor Arthroplasty System, spinal implants technology 

• Osteogenica - bone marrow concentration system 

• Fluidjet devices for open and MIS fusion, discectomy, artificial nucleus, and artificial disc procedures 

• Minimally invasive fusion system 

• Next-generation fusion, motion sparing, and minimally invasive spinal implant products 

• Bioactive synthetic bone graft substitute that is osteostimulative, osteoconductive, antimicrobial, and hemostatic 

• Orthopeutics, LP introduces Intrabrace a new non-surgical, injectable treatment for resisting spinal curvature in scoliosis. 

• 1-Synthetic alternatives to autograft/cadaver-based bone material, 2-Surgical hemostat as an adherent matrix/impermeable barrier to blood flow, 3-Bone augmentation material for injections in osteoporotic spines to treat vertebral compression fractures 

• Compliant artificial lumbar disc with graduated modulus for restoration of normal spine biomechanics/enhanced durability 

• Nucleus replacement device 

• Lumbar spine motion preservation via dynamic stabilization utilizing a semi-rigid rod and screw system 

• Lumbar, thoracic, and cervical fusion devices including less invasive instrumentation; lumbar and cervical artificial discs 

• Advance and commercialize less invasive spinal deformity surgical treatment without fusion 

• Clinical expertise, facility development, new technology, and business services including marketing and contracting 

• Interspinous process implant to treat Lumbar Spinal Stenosis (LSS) 

• Telemeterized natural motion elastomer disc 

• Least invasive approach for the delivery of lumbar fusion and motion preservation therapies 

• Minimally invasive dynamic stabilization device 

• High Intensity Focused Ultrasound for minimally invasive thermal treatment of disc herniation without disc penetration 

• Interactive intraoperative CT scanning technology for image-guided interventions 

• Microplate-based electronic biosensor system for label-free, real-time cell based assays 

• Noninvasive monitor to measure exhaled nitric oxide for the management of asthma 

• A device for the left atrial appendage for stroke prevention in patients with atrial fibrillation 

• Device for the treatment of Barrett's esophagus and prevention of esophageal cancer 

• Blood test for breast cancer measuring 5 protein biomarkers using super-sensitive ELISA with 95% accuracy 

• Totally implantable LVAD that does not interface with circulating blood 

• Percutaneous access management system to provide early ambulation/eliminate major complications, leaving nothing behind in patient 

• Molecular FingerPrinting process for early-stage diagnosis of cancer, enabling point-of-care therapeutics based on gene regulation 

• Percutaneous noninvasive heart valve replacement 

• Microsyringe delivery of cells, genes, and drugs to the vasculature/deep tissues of the body 

• Electronic pill for oral delivery of low bioavailability drugs 

• Bioabsorbable drug eluting stents and stent coatings for treatment of vulnerable plaque and coronary stenosis 

• Implantable Left Ventricular Assist Device (LVAD) for heart failure, needed by 250,000 Americans yearly 

• Blood test that screens/diagnoses cervical cancer without need of a cervical exam/pap smear 

• Capture and analysis of heart sounds leading to rapid and accurate diagnosis of cardiac pathologies 

• Non-contact intelligent medical vigilance for the hospital 

• Hydrus' Hydrocell - controlled fluid delivery system for every medical application without batteries or power cords 

• Genetic and personal history based testing to predict age-specific risk of breast cancer diagnosis 

• IYIA has developed a proprietary, clinically effective device, O2Misly, for treating slow healing foot wounds, primarily diabetic foot ulcers 

• Enteric Dialysis with Kibow Biotics - a food-grade microbial Gel cap formulation towards kidney failure applications 

• Noninvasive Ultra-WideBand medical radar imaging for cardiopulmonary ambulatory monitoring and diagnosis 

• Light-based therapy for eradication of ulcer-causing Helicobacter pylori 

• Device for the treatment of mitral regurgitation and heart failure without requiring open heart surgery 

• Interventional catheter-based system precisely measures stent and arterial size and cardiovascular repair tissue patch products 

• Colon cancer screening and preventing Fecal Occult Blood Test & the O'Regan Hemorrhoid Banding System 

• Long-term, miniature drug delivery implant with physician- controllable, zero-order release characteristics 

• Minimally invasive surgical access system used in laparoscopic surgery 

• Automated implantable pump systems for moving fluids around inside the body 

• Nitric oxide releasing surface treatments for enhanced biocompatibility in medical devices 

• Devices for mechanically induced bone growth, together with a "smart device" system for risk management 

• Xenograft/allograft stabilizing and terminal sterilization technologies for sports medicine and spine/neurology implantable devices 

• Unique microsphere-based technology for chronic/acute wounds 

• Affordable handheld metabolic monitor (indirect calorimeter) with both medical and consumer weight management applications 

• Noninvasive therapeutic ultrasound to enhance perfusion for treatment of acute myocardial infarction 

• In vivo plasmapheresis and ultrafiltration to remove excess fluid from CHF patients in clinical trials 

• Electrode sensor array, with integrated lead wires, simple, accurate and repeatable ECGs 

• Disposables for drawing blood -- percutaneous or from a catheter -- neonates to geriatrics 

• Biomimetic coronary stent coating that prevents restenosis/reduces the need for extended courses of dual antiplatelet therapy 

• Peptide-based therapeutic to enhance stent/graft patency 

• Minimally invasive device-based technologies targeting the treatment of hemodynamic instability and perfusion 

• 1-Bio-therapeutic designed from autologous stem cells and committed to a cardiac lineage before implantation, 2-Corresponding catheter for accurate transmyocardial injection 

• Noninvasive device using muscular counter pulsation (MCP) technology for the treatment of chronic heart failure (CHF) 

• Technology to reshape the heart 

• Catheter-based therapy which increases cerebral perfusion for the treatment of ischemic stroke and vasospasm 

• Stentless aortic valve prosthesis to be delivered via catheter 

• A noninvasive test for endothelial dysfunction using digital (fingertip) thermal monitoring 

• Perfusion monitoring for preventing septic shock, the greatest hospital mortality 

• PeriVasc 

• Minimally invasive interventional radiology/vascular surgery devices 

• AUDICOR uses advanced ECG-heart sound analysis to enable superior diagnosis/monitoring of CHF/ACS patients 

• Pressure and flow sensing systems for vascular and other applications 

• Percutaneous mitral valve repair simulating precision of surgical annuloplasty 

• Surgical and percutaneous cardiac valve repair 

• Minimally-invasive cardiac implantable devices for treating mitral valve regurgitation without atriotomy or cardiopulmonary bypass 

• A wearable continuous ultrafiltration device that removes fluid overload in patients with Congestive Heart Failure 

• ALGEL 

• A portable laseroptical system for noninvasive differentiation between ischemic stroke and spontaneous intracerebral hemorrhages 

• OmniWave 

• A platelet reactivity test to measure the effect of anti-platelet drugs, particularly aspirin and Plavix 

• An approach using RF energy for shrinkage of the valve annulus to reduce/eliminate regurgitation 

• Catheter-based photoreactive treatment system for endovascular intervention in coronary and peripheral atherosclerotic disease 

• Minimally invasive telemetric and continuous measurement of left atrial blood pressure at heart failure 

• Noninvasive medical device providing low-risk hypoxic treatment that induces appetite suppression and weight loss 

• Multi-Sensing Wireless Catheter platform attached along the GI-Uro tract detecting GERD, incontinence, and other abnormalities 

• SutureLock - a versatile suture-securing knot-replacement device for endoscopic wound approximation 

• Microscope slide scanners and information management software that enable the digitization of pathology 

• Patient recovery system for cosmetic and reconstructive surgery 

• System analyzes a patient's susceptibility to cardiac arrest and consequent need for implantable defibrillator 

• Interventional MRI technology for cardiovascular imaging including detection/treatment of vulnerable plaque 

• Point-of-care IVD platform that provides rapid, accurate, automated laboratory testing using low cost, disposable biochips 

• ATRILAZE 

• Digital 3-D visualization for microscopy 

• Dedicated angioplasty and stent systems for the treatment of arterial bifurcations 

• Specialty and standard electrophysiology catheters that have superior performance, advantageous features, and are affordable 

• Nanotechnologies for use in orthopedic implants, dental implants, and stents 

• Noninvasive neural vision enhancement 

• Disposable, noninvasive, pump-less, and valve-less automatic blood pressure monitor "on-a-chip" 

• Saliva-based consumer diagnostic systems, which enable the development of personalized therapeutics 

• RFID hardware and software platform for test tubes/ apheresis device for blood component separation 

• 3-D tomographic ultrasound imaging system to aid in diagnosing breast cancer 

• Infusion catheter for treatment of tumors which are unresponsive to systemic chemotherapy by the local delivery of drugs and other agents 

• Customized miniature disposable stereoscopic cameras that provide 3D vision, measurements, and image fusion in real-time 

• Medical devices that enable diabetes disease management and the prevention of lower extremity amputations 

• Expert systems and miniaturized hardware for stroke prevention and management and for pre-operative brain protection 

• Dynamic optimization of pacing intervals according to hemodynamic sensors for CRT devices 

• SmartStep 

• Cellular implants for orthopedic, trauma, and spinal applications based on a biological form stable matrix 

• Endoscopically-placed devices to prevent GERD, obesity, and irritable bowel syndrome (IBS) 

• 1- Interventional single-use cardiac support device and drug delivery platform, 2- Implants for use in/with magnetic resonance imaging (MRI) systems 

• Bioabsorbable, bioactive, and drug-releasing medical device products for various fields of surgery 

• Coronary guidewire, to provide real-time ultrasonic measurement of coronary arteries to determine stent size and apposition without exchange of catheters 

• Miniature implantable, continuous blood glucose sensor for diabetics, incorporating noninvasive wireless monitoring 

• Tissue fixation implants, injectable bone grafting biomaterials, and tissue scaffolds with drug releasing properties 

• Non-invasive screening of Peripheral Arterial Disease (PAD), combining postural/infrared blood volume testing 

• Medical devices utilizing radiofrequency and microwave energy which are cost-effective and clinically relevant 

• Unique add on and removable needle safety product that fits to standard glass/plastic syringes 

• Non-invasive airway clearance in ICU patients to prevent ventilator associated pneumonia 

• Technology for the manipulation of adult stem cells to repopulate chronically diseased liver tissue 

• Products that digitize manual breast examination tissue elastic properties into objective computerized visual maps/reports 

• Endotracheal tube with video, self-locking orthopedic implants, structured TPN lipids, cell therapy for cancer, etc. 

• Immediate, active, device-less, and painless topical drug delivery, of small/macromolecules, for local/systemic indications 

• Transdermal delivery system of levodopa (L-DOPA) for the treatment of Parkinson's Disease 

• Magnetically actuated telescopic intramedullary (IM) nail activated by an induced low power directional magnetic field 

• A suite of tools for automated CT Angiography (CTA) diagnostics for Coronary Artery Disease 

• Noninvasive, outpatient bariatric device for overweight/obesity 

• Microsensors and receptors for the real-time measurement of therapeutic drugs and clinical chemistry parameters 

• Bifurcated coronary stent 

• SurfLink 

• Next-generation bio-medical adhesive, used as a filler for aneurysms in various areas of the body 

• Vascular stents and grafts with increased patency by improved flow dynamics, reducing stenosis and restenosis 

• Non-invasive continuous measurement of tissue oxygenation for various intraoperative and post-operative applications 

• A platform aerosol drug delivery nebulizer device for multiple- and single-use applications with disposables 

• Gene-based products for the diagnosis and treatment of spinal disorders 

• The Axya Shoulder Fixation System generates ultrasonic energy for knotless suture welding in shoulder surgery 

• Minimally invasive percutaneous neuromodulation pain therapy 

• Ultraviolet light technologies for the inactivation of RNA viruses in/out of the body 

• Noninvasive mechanical compression for treatment/prophylaxis of lower extremity circulatory disorders such as: PAD/DVT 

• Rapid testing systems led by the Growth Direct 

• Laparoscopic surgeons maintain direct control of the laparoscope movement/placement with GMP's Laparocision 

• Fiber-optic, catheter-based, near-infrared (NIR) spectroscopy system to identify lipid rich plaques in the coronary arteries 

• Small/portable/handheld device for diagnosing brain hematomas 

• Real-time, noninvasive monitoring of blood loss, anemia, and other vital blood measurements 

• A remotely controlled, wireless-powered implantable 230-channel nerve stimulator built on a 15 

• Aesthetic treatment device using collimated high-energy light and laser, delivered simultaneously by fiber delivery system 

• Multi-channel implantable microelectrodes for deep brain stimulation and recording, enabling enhanced neuromodulation therapies 

• Ultrasonic medical devices for minimally invasive therapeutic procedures for treatment of cancer/other healthcare purposes 

• Drug/device products for post-operative pain and orthopedic drug delivery indications using syntinate synthetic absorbables 

• Biomaterial that regulates resorbability and enhances bone regeneration 

• Image-guided therapy for metastatic liver disease 

• Post-proteomics multiplexed MS-based diagnostics/theranostics linked to drug development and personalized medicine 

• A "preventative" vaccine for HIV-AIDs 

• Respiratory diagnostics for noninvasive assessment of airway acidification in Asthma, COPD, and GERD 

• Theramers 

• Laparoscopic surgical access technology based on a No-Seal platform 

• Medical devices, utilizing robust tyrosine-based resorbable polymer systems/pharmaceuticals in surgical barriers/cardiac rhythm management 

• Phase-shifting technology for Contrast Ultrasound imaging 

• Miniature/patient-controllable/valved catheter to improve quality of life/decrease urinary tract infections in patients suffering urinary retention 

• CGRP for the treatment of heart failure 

• Noninvasive device providing substitute vestibular sensory information through the tongue for treatment of balance disorders 

• PuraMatrix injectable synthetic nanofibrous hydrogels for bone, cartilage and soft tissue regeneration, and drug delivery 

• Implanted oscillating field stimulation device which regenerates acute and sub-acute damaged spinal cord nerve tissue 

• Synthetic bone that duplicates the microstructure, composition, and performance of human bone 

• Drug product for the treatment of acute spinal cord injury, cancer, macular degeneration, and glaucoma 

• Nitric oxide-based therapies to accelerate healing of tendon, bone, and other musculoskeletal tissue 

• Biomaterials-based product that augments or replaces the diseased nucleus pulposus of the spinal disc 

• A CE-marked resorbable plating system for cervical fusions allowing for load sharing 

• Low-profile implants/less invasive surgical instruments to treat spinal disorders utilizing fusion and non-fusion technologies 

• A biological and mechanical solution to annular repair and spine fusion 

• Fusion technology platforms and second-generation artificial discs for the lumbar and cervical spine 

• Noninvasive, ambulatory, portable, 3-D traction technology providing an effective and unique therapy for spinal disorders 

• Real-time image-guidance technology with an FDA-accepted accuracy claim of +/-1mm at 1 meter 

• Lumbar dynamic stabilization with MIS compatibility and pedicle screws 

• Rapid table-mounted retraction/surgical site access for MIS placement of hip/knee/shoulder/spine implants 

• Emperor Mobile Spinal Disc, P.E.E.K Cages, Pedicle Screw System, and Saturn Hip Resurfacing 

• Stable and extractable self locking intramedullary nails and proximal femoral fixation 

• 1-LIFEBACK® Spine Programs for non-operative and post-operative spine patients and 2-the LTX 3000® Rehabilitation System 

• Shielded reciprocating tissue sculpturing instrument, able to navigate into neural foramen to relieve nerve compression 

• Catheter-based technology for orthopedic trauma indications providing site-specific tissue drainage and drug delivery 

• Facet fixation system that is a less-invasive/faster alternative to pedicle screw fixation 

• Naturally-derived/non-crosslinked/collagen-based extracellular matrix to repair/remodel damaged tissues 

• Smart devices to harness human physiology for health care, industrial safety, and law enforcement applications 

• Analyze, search, store, mine, share and unlock the power of digital tissue images 

• A protein therapeutic biotreatment that regresses solid tumors and protects against relapses 

• Functional brain imaging centers that identify Alzheimer's, brain injury, stroke, ADHD, bipolar, depression, anxiety, OCD 

• Orbital atherectomy for the treatment of peripheral vascular disease 

• MIS platform technologies for creating cavities in tissue and partially molding an orthopedic implant in situ 

• Porcine-derived tissue devices for ligament, cartilage, bone, and soft tissue replacement and augmentation 

• Physiologic Heart Surgery Pump: reducing post-surgery kidney failure, mortality, and complications cost by 50% 

• Next-generation estrogen-based drug-eluting coronary stent and an orthopedics/sports injury pain management device 

• Repositionable/removable percutaneous heart valve, precision controlled delivery device, and calcified valve encapsulation system 

• Free-floating optical probe with multiple LD scanning and magnetic stabilization for noninvasive blood glucose monitoring 

• Flash Ultrasound 

• IBraces - 100% customized, invisible orthodontic braces designed for efficient, effective treatment of teens and adults 

• PowerCosmetics micro-electronic patches, delivering skincare results faster and more effectively 

• Surgical stapling devices for open and laparoscopic procedures developed for the growing China market 

• Noninvasive device used in the differential diagnosis of disc or facet mediated low back pain 

• Biocompatible polymer implant to prevent or reverse the progression of chronic heart failure and mitral valve regurgitation 

• 1-Low-cost, disposable point-of-care (POC) Pap smear replacement requiring no lab or medical professional; 2-Drug-eluting contraceptive cervical barrier 

• Accommodating and multifocal phakic IOLs, CE-approved for $ billion refractive IOL market 

• An implantable ophthalmic device to treat vision correction associated with Age-Related Macular Degeneration (AMD) 

• Noninvasive medical device for the treatment and prevention of obesity using controlled hypoxia 

• Next-generation biomaterials technology 

• Percutaneously delivered implantable system to treat mitral valve regurgitation and improve congestive heart failure 

• A bioactive ceramic that delivers better/faster spine fusion and bone repair 

• A drug delivery platform that approaches the endovascular bifurcation challenge from a completely different angle 

• The Nano-Pulse measures arterial elasticity and autonomic nervous system function 

• NICOM 

• Advanced optical systems/services that are changing the way doctors evaluate and treat the eye 

• Advanced skin biopsy and wound healing solutions to dermatology, cosmetic, primary care, and oncology clinicians 

• Tissue repair devices exploiting shear force transfer and large-interface substrates for adherent new tissue formation 

• Technology that prepares the spinal disc for a nucleus replacement/minimally invasive fusion device 

• An internal adhesive biotechnology designed for strength, biocompatibility, and ease-of-use with applications in cardiovascular surgery 

• 1-Instant-on/instant-off proximal occlusion funnel catheter, 2-Scoring balloon with drug delivery capability 

• Protein free induction of endochondral ossification, no human origin, not contagious, no soft tissue ossification 

• 1-Cartilage implant for the knee, 2-Injectable cell therapy for the spinal disc/nucleus, 3-Bone graft extender to treat spinal deformities 

• Percutaneous light activation reduces intra-abdominal fat, returning Type 2 diabetic patients towards normoglycemia 

• Diagnostic platform with a test for measuring unbound Bilirubin for the management of newborn jaundice 

• Digital Pulse Analyzer - provides early detection of arterial wall stiffness and biological age of arteries 

• Endothelial management - less trauma combined with new agents for improved healing in vascular interventions 

• Robot-assisted stroke therapy devices 

• The Sensation 

• Resorbable pegylated hydrogel for surgical wound sealing/adhesion prevention/sustained and targeted drug delivery 

• ECG software for assessing acute ischemia and cardiac safety surrogates in clinical trials 

• Spinal implants utilizing elastomeric polymers for non-fusion treatment of disc degeneration 

• Blood tests for: breast cancer/Alzheimer's disease/women's cancers 

• Gradient-based tracking and navigation for MRI - enables MRI-guided intervention, endoscopy and catheterization on any scanner 

• Programmable lab-on-a-chip platform for applications ranging from drug discovery to consumer diagnostics 

• Lectin-based cell adhesion technology which enables stents that traffic cells in the bloodstream 

• Tools for enabling adult stem cell based regenerative medicine 

• ViaDerm - home use transdermal drug delivery system creating microscopic passageways in the top skin layer 

• Ambulatory infusion pumps and disposables that require no programming and use pre-filled solution containers 

• High Intensity Focused Ultrasound for incisionless male surgical sterilization 

• Highly reimbursable orthopedic rehabilitation durable medical equipment 

• Noninvasive blood glucose monitor that will measure glucose in sweat in a disposable dermal patch 

• 1-Soft tissue attachment nanotechnology, 2-Bioactive/biocompatible/osteoconductive synthetic bone filler, 3-Biodegradable fiberglass fiber & composites 

• Disease management system for early detection of heart failure using a noninvasive cardiovascular-sleep prognostic marker 

• Wireless 2000 leads the un-tethered patient vital signs monitoring revolution, using wireless Ultra Wideband (UWB) and Zigbee technologies 

• Biocellulose technology that eliminates the risks/complications/limitations inherent in animal, human, and synthetic biomaterials 

• Spinal implants, cervical, thoracolumbar, interbody, bone substitutes, motion preservation 

• Tumor necrosis factor alpha (TNF-a) inhibitor therapy for treatment of chronic persistent radiculopathy (including sciatica) related to disc herniation. 

• Building on an exclusive intellectual property platform for both fusion and non-fusion products 

• Disc Motion Technologies has developed the first posterior lumbar arthroplasty system consisting of an artificial lumbar disc and a posterior dynamic stabilizer. 

• Motion preservative artificial disc 

• Revisable cervical and lumbar total disc replacement that can be converted to fusion 

• Water-resistant adhesives derived from mussels, used as tissue adhesives/anti-bacterial coatings 

• 1-Lumbar cage with integrated fixation screws, 2-Pedicle screw product line, 3-Access systems and implants for use in minimally invasive surgery (MIS) 

• Reintroducing CHYMOPAPAIN, the only proven minimally-invasive therapy for herniated discs; it allows nuclear regeneration. 

• Lumbar system for dynamic stabilization without fusion, artificial discs, and minimally invasive surgery systems 

• Orthopedic products, specifically for upper and lower extremity small bone applications 

• Developing and marketing EEG systems, tools and services for Neurologists, Neurosurgeons, and Neuroscience Researchers 

• Indigo Orb, Inc is a technology leader in "Automatic Detection of Epidural Cavity" 

• Human Globin, a biopolymer to replace animal collagens in dermal fillers and create biomaterials for tissue repair 

• An automated blood glucose monitor for the intensive care unit using near infra-red spectroscopy 

• Minimally invasive surgical technology that uses ionizing radiation to treat wet age-related macular degeneration (AMD) 

• Minimally invasive ophthalmic device therapy for Dry Macular Degeneration and other blindness causing diseases 

• Providing private and hospital-based OB/GYNs, Perinatologists, and Radiologists with integrated reporting and image management systems 

• Single-use rigid endoscopes, with superior image quality, at a reduced per-use cost 

• Portable and networked medical devices such as handheld ultrasounds 

• Non-surgical serum based cure, proven effective for PAD, Diabetic and Cardiovascular disorders 

• Producer of surgical devices including a self-attaching hernia patch, anti-clog surgical drain, and cavity implosion device 

• DART is utilizing an interstitial radiation source that by nuclear decay recoil mechanism emits high-energy alpha particles widely dispersed by diffusion and by convection in the tumor mass 

• BMDSys' Magnetic Field Imaging (MFI) is an absolutely non-invasive, radiation- and side-effect free electro physiological high speed cardiac diagnostic system to identify upcoming heart attacks and sudden cardiac deaths 

• Developing a fully implantable extra-aortic counterpulsation device designed to provide long-term, cost-effective treatment and significantly improve quality of life for heart failure patients 

• Intelligent nasal drug delivery devices for topical, systemic and nose-to-brain applications 

• Handheld device which measures the amount of calories a person requires to maintain body weight 

• Minimally invasive retractors for pelvic surgery to optimize pneumoperitoneum pressure and patient position (OP5) 

• Open-architecture, cryogenic-free MRI systems for orthopaedic, general purpose and interventional applications 

• Growth factor and biomaterial addressing the needs of spinal fusion, osteochondral defects, osteoarthritis, dental medicine, and other indications 

• Non-invasive continuous glucose monitoring device, for patients with diabetes, based on a multi-sensor platform 

• Percutaneous mitral valve replacement system for treatment of mitral regurgitation 

• Total hip replacement system that addresses resistance to wear and resistance to dislocation with ceramic and double mobility 

• Next-generation disposable colonoscope incorporating diagnostic/therapeutic capabilities allowing for a potentially sedation-less treatment 

• Computer-integrated robotic instrumentation/navigation tools for orthopedic surgery 

• Dual-function, automatic, handheld sinus irrigator and aspirator 

• Less invasive orthopaedic implant solutions employing advanced pliable structured materials and innovative designs 

• Patient controlled analgesia device for pain management 

• Target-specific recombinant human protein focused on spinal fusion surgery 

• Ceramic components for spine, orthopaedic, and other implant needs 

• Non-invasive robotic radiosurgery system for cardiac ablation 

• Integrated wireless monitoring 

• Device based therapy targeting ischemic brain stroke and chronic heart failure 

• Site-specific catheter-guided system to deliver drugs and biologics directly to the adventitia 

• Portable, easy-to-use consumer device that allows for easy, safe and green disposal of used insulin syringes, lancets and pen needles by vaporizing the sharp 

• Portable and easy-to-use tests for the healthcare, veterinary, and consumer markets 

• High-intensity focused ultrasound in a catheter to treat atrial fibrillation 

• Technology using opto-acoustics for functional imaging/cancer diagnosis 

• Infusing normothermic fluids from 10mL/hour-1200mL/minute with 30-second setup through a disposable cassette 

• Methods for treating human tissue based on volumetric bipolar radio frequency ablation (RFA), and surface ablation of tissue 

• Cell-based epicardial patch designed to promote blood vessel growth in ischemic cardiac tissue 

• Human bionic devices that can instantaneously interact with the human body to replace or restore biomechanical or physiological functions 

• Advanced wheelchair technologies 

• Catheter-based devices which rapidly provide quantitative data to the physician about vessel and stent size, suitable for peripheral and cardiac applications 

• Diagnostic methods using microarray gene expression profiling to determine specific properties of tumors 

• Laser, light-based, and radiofrequency devices for aesthetic and medical applications 

• Optical backscatter technology to improve the way cancer is detected and diagnosed 

• Advanced gene expression and DNA quantification products and services 

• Mobile phone-based data collection for chronic disease management 

• StomaphyX™, a sterile, single-use device for use in endoluminal trans-oral tissue approximation and ligation in the GI tract 

• A software based thermal mapping system that will be used in conjunction with CT and planar x-ray imaging systems 

• EXPANSE Vertebral Body Replacement Device for use in the thoracolumbar spine 

• Low-cost, fast, and accurate molecular diagnostic products 

• Devices for the in-office polypectomy/myomectomy market 

• Next generation of laser therapy 

• New pulmonary drug delivery system 

• Molecular diagnostic products for laboratories that are intended to enhance medical care by providing early diagnostic information rapidly 

• Products for the minimally invasive repair of long bone fractures 

• Electromedical/electrotherapeutic equipment 

• Female sterilization technology 

• Precision surgical systems for computer-assisted 3D planning, surgical navigation, and surgeon-controlled robotic surgery 

• Devices for treating cardiovascular disease 

• Telemedicine paired with state-of-the-art ophthalmologic imaging 

• Low cost, easy-to-use, credit-card-sized devices which will allow on-the-spot quantitative diagnosis 

• Noninvasive breast cancer risk assessment device 

• Non-invasive, painless, Navigated Brain Stimulation (NBS) for brain diagnostics and therapy 

• Non-invasive ultrasound body contouring 

• A device that seals blood vessels after hemodialysis as an alternative to central venous catheters for kidney-dialysis patients 

• Fusion and non-fusion spinal implants 

• First viable intracellular genetic protein therapy for the treatment of Chronic Heart Failure ("CHF") 

• Modular hip stem technology and total knee replacement systems 

• Advanced endotracheal tube for intubation, fitted with advanced fiberoptic visualization technology 

• Interventional bronchoscopy devices for lung diseases 

• A portable oxygen delivery and ventilation system 

• Metabolomic profiling of biomarkers for the diagnosis of early forms of dementia and neurodegenerative diseases 

• Neowater®, a water-based nanotechnology which has physical properties that mimic intracellular water 

• AOKit™-bio: an adaptive optics kit for biologists which enhances microscopic imaging 

• Minimally invasive medical devices for patients who are at risk for or have suffered a stroke 

• Products to diagnose the risk for heart attacks by means of assessing endothelial function 

• Ophthalmic formulation of mitomycin-C in a single-use kit, for use in the surgical treatment of glaucoma 

• Arm training device to restore arm movement in stroke patients who have experienced arm paralysis 

• Wireless seizure alarm systems for people with epilepsy 

• RNA-based therapeutics 

• Automatic tools to support image visualization, lesion detection and quantification, temporal evolution assessment, and automatic reporting in chest and abdominal CT scans 

• A portable breath collection apparatus (BCA) which can collect breath samples virtually anywhere, for highly sensitive laboratory analysis 

• Transvaginal, ultrasound image-guided HIFU device, capable of real-time guidance and monitoring of therapy 

• Minimally invasive catheter-based ablation technologies to treat atrial fibrillation and other cardiac arrhythmias 

• Devices that use bio-electric stimulation therapy (bio-current) to treat hard-to-heal wounds 

• Miniature blood pump, designed to be placed superficially like a pacemaker, for the long-term treatment of chronic heart failure (CHF) 

• Biodegradable surgical adhesive for seroma reduction in plastic surgery 

• SutureCross™: Knotless Anatomic Fixation System for double row arthroscopic rotator cuff repair 

• New generation of high-power/compact lasers for cosmetic, dermatology, pain management, and wound applications 

• Contrast agents/molecular imaging for detection using a modified porous Silicon (mpSi™) platform 

• Delivery of proteins and peptide drugs without burst, with near-zero order release, and with high bioavailability 

• Monitoring system to replace the manual assessment of labor progress with real-time/continuous information 

• Bone cement to replace PMMA-based materials 

• Easy-to-use, instrument-free, disposable molecular diagnostic tests 

• Third-generation biodegradable annuloplasty rings 

• Low-mass PFO closure system capable of repairing the defect from within the tunnel 

• BQT®, a non-invasive point-of-care diagnostic test for osteoporosis and bone fracture risk 

• Optical cell sorters used in stem cell/cell therapy treatments for cancer, autoimmune disease, and regenerative medicine applications 

• Non-fusion spinal solutions that control segmental motion/maintain the neutral zone simultaneously 

• Wireless electronic skin patch sensors for the real-time measurement/monitoring/diagnosis/clinical management of cardiac arrhythmias 

• Optical coherence tomography for evaluation of human tissue microstructure with real-time depth visualization 

• Non-molecular bacterial screening, identification, and antibiotic susceptibility testing 

• The CADscreen system performs a non-invasive, 30-second test to identify the risk of heart disease 

• Products for the early detection of lung and oral cancers 

• A "plug & play" system for treating non-invasive, curative, and palliative cancers and precursors 

• Fully modular total hip replacement systems to reduce wear/add longevity 

• Spinal cage with dynamic stabilization/MIS placement (3mm access) and easily revisable 

• Hand-held device to monitor post-operative/trauma patients for early warning signs of sepsis or infection in the bloodstream 

• Patient-centric data system and analysis tools for translational medicine and research 

• A minimally invasive electromagnetic navigation system for early detection of lung cancer 

• Advanced suturing technology for minimally invasive/NOTES/bariatric/cardiac/other surgical specialties 

• Bioprosthetic heart valve with a percutaneously-exchangeable leaflet set that provides lifetime service without anti-coagulation therapy 

• Combination ultrasound/electrical stimulation device for skin rejuvenation 

• Multi-pixel x-ray source for enhanced system performance/new capabilities 

• Video integration and equipment management system to enhance the MIS market 

• Detection products for viral/bacterial infections, genetic diseases, mutations, cancers, etc. 

• 1-Painless intradermal drug delivery, 2-GERD diagnostic device, 3-Non-invasive continuous glucose monitoring 

• Biomarker assays for the early detection of cancer 

• Ankle replacement implant for patients with chronic pain/arthritis 

• Silk-based biomaterial platforms for tissue rejuvenation/connective tissue repair 

• Biodegradable synthetic hydrogels for general and specialty surgery use 

• Minimally invasive, single-procedure approach for the repair of cartilage damage/osteoarthritis 

• Particle technologies for the treatment/prevention of chronic respiratory disorders 

• Hands-free internal retractor/internally-anchored laparoscope camera cleaner 

• Minimally invasive devices that improve oxygenation for patients with COPD 

• A unique solution similar to ring annuloplasty/edge-to-edge repair, all in one modality, for mitral valve repair 

• Transdermal/wound dressing/mucosal drug delivery 

• Biomaterials-based medical devices focusing on cardiovascular, metabolic, inflammatory, and fibrotic diseases 

• Single molecule DNA analysis system, with no requirement for prior sequence information/PCR/cloning/probes 

• Dynamic "shape memory" platform to optimize mitral/tricuspid valve repair 

• Unique transcranial magnetic stimulation system that allows direct non-invasive activation of deep brain structures 

• Devices for Natural Orifice Translumenal Endoscopic Surgery (NOTES) procedures 

• Unique spinal implant designed to promote rapid fusion 

• Fast, accurate, and easy-to-use in vitro molecular diagnostic products that rapidly identify infectious pathogens 

• Electrosurgical instruments 

• Minimally traumatic, bone- and cartilage-preserving knee implants and instrumentation 

• Neuromodulation system for both traumatic brain injury (TBI) and stroke 

• Inferior vena cava filters 

• Plastic medical devices for gynecological exams and surgeries 

• Ventricular elastic support therapy for heart failure 

• Kidney stone management device and urethral dilating introducer 

• A minimally invasive device for stomach-reduction surgery consisting of a stapling tool that can be passed down the throat into the stomach 

• Minimally invasive therapy for the treatment of chronic disc pain 

• Advanced detection, staging, endoscopic treatment and follow-up care for acute and chronic lung disease 

• Off-the-shelf implantable allograft tissue to support peripheral nerve repair and regeneration 

• Minimally-invasive percutaneous aortic valve replacement systems 

• Cellular imaging technology, using the Internet to transfer real-time/secure/accurate cellular resolution images 

• Deep brain stimulation (DBS) guidance system 

• Customizable vibration therapy devices to stimulate bone/muscle tissue 

• Cellular therapy device to treat liver disease 

• Treatment for ischemia via stem cell-based therapies 

• Minimally invasive therapies for interventional neuroradiology 

• Drug delivery vehicles that can easily be targeted to specific cell types/disease state tissues 

• Bioabsorbable implants for accurate soft tissue fixation either to apposing soft tissue/to bone 

• Bifurcated stenting 

• Non-intrusive patient-monitoring systems that facilitate timely intervention for cardiac/respiratory deterioration 

• Simple, low-cost infusion pump that contains the IV bag within it 

• Human-based tissue scaffolds 

• Minimally invasive vapor technology to treat emphysema 

• Stent that provides protection from embolic showers during/post-procedure 

• Real-time imaging/image guidance for the operating room 

• Tissue engineering technologies for orthopedic/sports medicine patients 

• Anatomically-driven/minimally invasive spinal products for motion preservation 

• Technologies to treat obstructive sleep apnea and snoring 

• Tibial knee implant for stable fixation to the medial tibial plateau without bone cuts/cement/screws 

• Silicon nitride implants with 3-D structured cancellous ceramic for strong capillary action 

• Tissue repair/surgical mesh systems for soft tissue repair 

• Implant designed to retain motion following the removal of diseased disc and/or bone material in the upper spine 

• Minimally invasive disc augmentation system to repair/rehabilitate an intervertebral disc 

• Intelligent microgels as injectable scaffolds for intervertebral disc repair 

• Hydrogel matrix with applications across multiple specialties 

• Intradiscal arthroplasty device utilizing articulating PEEK-on-PEEK material 

• Next-generation of biomaterials for spinal implants 

• Artificial cervical disc with controlled range of motion in all six degrees of freedom 

• Second-generation, metal-on-metal cervical/lumbar artificial discs 

• Products for nuclear replacement/augmentation, vertebral compression fracture repair, and spinal fusion 

• New unilateral posterior fusion technology 

• Next-generation spinal implants 

• True 3-D imaging to improve evaluation/planning of radiation treatments 

• Disposable devices for Natural Orifice Translumenal Endoscopic Surgery (NOTES) procedures 

• Bioresorbable peripheral/coronary polymer stents that promote the natural remodeling of an injured artery after angioplasty 

• Resonating sensor made out of piezoelectric ceramics that can be miniaturized and is suitable for use in diagnostic equipment 

• Miniaturized ultrasound probe that is easier-to-use/more flexible 

• Medical devices for the osteoarthritis/rhinosinusitis markets 

• Percutaneous mitral valve replacement (PMVR) for Mitral Regurgitation (MR) 

• A platform for minimally-invasive cardiac surgery (MICS) via single-port, subxiphoid access, and an endoscope that reaches any anatomical location, including complex paths, from one single access port 

• Plaque vulnerability biomarkers to detect patients at risk for the development of stroke, myocardial infarction or claudication 

• Minimally invasive surgical procedure intended to reduce the incidence of stroke/thromboembolism associated with atrial fibrillation 

• Miniature intravascular flow augmentation device for every organ that needs temporary change of flow 

• Device to percutaneously repair the mitral valve 

• Non-epigenetic cell reprogramming technology that enables the generation of patient-identical replacement tissue/organs on an as-needed basis 

• Transcutaneous yet needleless drug delivery system for the injection of drugs/vaccines in solid doses 

• Microcatheter and imaging technologies for interventional ophthalmology 

• Miniature patch that dispenses insulin 

• Multi-generational devices using hybrid technologies for Natural Orifice Translumenal Endoscopic Surgery (NOTES) procedures 

• Wearable artificial kidney device 

• Products to diagnose/treat dry and wet age-related macular degeneration (AMD) and other chronic diseases involving the alternative complement system 

• Non-invasive measurement of magnetic fields to diagnose functional brain disorders 

• Minimally invasive system for treating long-bone fractures using an intermedullary stent/cement 

• Next-generation/fully-automated/electronically-controlled/self-contained blood glucose system 

• Device to improve drainage following heart, lung, and trauma surgery, as well as other procedures where drainage is critical 

• Second-generation electronic retinal implant to treat blindness due to retinitis pigmentosa 

• Pulsatile perfusion generator technology to greatly enhance the preservation time window and organ transplant quality 

• Small/portable/disposable infusion pump kit to treat post-operative pain more effectively than narcotics 

• Computer-controlled pressure garments for the effective treatment of lymphedema/chronic wound healing 

• Neo-organs/tissues derived from the patient's own (autologous) cells 

• Stent technology for the treatment of atherosclerotic disease at/near bifurcations 

• Gene therapy products for the treatment of inherited/acquired diseases. 

• Non-invasive/fast/accurate diagnostic kits for: fertility, hormones, infectious agents, auto-antibodies, and tumor markers 

• Painless system that improves the appearance of cellulite/relieves minor muscle aches, pain, and spasms/temporarily improves local blood circulation 

• Devices to control bleeding post-hysterectomy/in other cases of pelvic area trauma 

• System to process/concentrate cellular components from autologous bone marrow, including adult stem cells, at the point-of-care and in just 15 minutes 

• Membrane optimization, coatings technologies, and development of polymers for biomedical applications 

• Bioactive glass-ceramic material that offers whiter and less-sensitive teeth while protecting from tooth decay 

• More targeted/accurate radiation of cancer cells with significantly fewer side-effects 

• Handheld/breath-based blood glucose monitor 

• Mesh wrap for permanent implantation around the heart to prevent/reverse the progression of heart failure 

• Next-generation cell-based/tissue-engineered products 

• Extracellular matrix derived from fibroblasts isolated from newborns (NO embryonic stem cells/animal products) 

• Direct/real-time/non-invasive vascular imaging via infrared light to visualize both superficial veins/more deeply-located arteries 

• Advanced, intuitive real-time imaging for abdominal minimally invasive surgery 

• Non-invasive, wearable, watch-sized metabolism measurement system that employs the use of a low-cost proprietary disposable sensor using direct-calorimetry, to accurately measure minute-by-minute caloric expenditures 

• De-cellularized biological scaffolds meant to function like native tissue 

• Wireless ECG monitoring 

• Protective coatings for medical instrumentation to combat bacterial biofilms 

• Advanced trilobal pericardial valve technologies 

• Joint prostheses as an adjunct to laminectomy/laminotomy/neural decompression/facetectomy, in lieu of fusion 

• Rapid DNA-based point-of-care diagnostics 

• Catheter-based drug delivery system designed to dissolve blood clots in a single/rapid/one-step procedure 

• Minimally invasive/flexible spinal implant technology to treat vertebral compression fractures and degenerative disc disease 

• Modified bioactive ceramics and second-generation tissue regeneration smart materials 

• Non-invasive electrocardiographic imaging 

• Third-generation cancer-associated biomarkers using proteomics 

• Technology for real-time identification/localization of cancer cell clusters to enable complete/residual-free therapeutic excisions 

• Catheter-based drug delivery using high-frequency/low-power ultrasound 

• Cerebral protection system to prevent embolic strokes 

• Non-invasive neurorehabilitation system 

• System that enables consistent tissue contact/complete lesions during cardiac surgery for the treatment of arrhythmias 

• More viable/cost-effective method for treating intracranial aneurysms 

• Short-pulsed/plasma-mediated electrosurgical instrumentation that avoids extensive collateral damage 

• Single, multi-cannula laparoscopic port and specially designed curved instrumentation 

• Fluid-controlled accommodating intraocular lens (IOL) to restore vision of youth to middle-aged/elderly individuals 

• Non-invasive/urine-based diagnostic assays for specific cancer types 

• Natural cell-based technologies to restore normal neuron function in the central nervous system 

• Less invasive devices for the treatment of glaucoma, intended to replace current therapies 

• Minimally invasive/RF nerve ablation to reduce of migraine headache pain 

• Implantable cardiac monitoring/patient alerting system for ischemic events to reduce time to treatment 

• 3-D tracking devices for use in surgical navigation and MIS 

• Line of antimicrobial coatings to prevent microbial colonization/biofilm formation of endotracheal tubes/other indwelling medical devices 

• Device for the treatment of sudden cardiac arrest for both in- and out-of-hospital markets 

• Non-invasive infrared imaging system for the early detection of breast cancer 

• 1-Percutaneous venous valve, 2-Inferior vena cava filter, 3-Multi-purpose/disposable laparoscopic scissor grasper, 4-Multi-sized/multi-stiffness guidewire 

• Light-activated drug therapy to transform cancer into a treatable chronic disease 

• Technologies that will prevent infection for many large patient populations 

• Disposable laboratory-on-a-card ("lab card") device to deliver sample-to-result analyses in minutes at the point of patient-caregiver contact 

• Biocompatible shape memory polymers which can be programmed to change shapes/rigidity when an initiating stimulus is applied 

• Therapeutic approaches to prevent the abnormal tissue growth that inhibits recovery from surgical procedures/impairs normal wound healing 

• System to inactivate pathogens in all three major blood components: platelets/plasma/red cells 

• Electromagnetic thermal therapy to relieve pain/improve function in patients suffering from osteoarthritis 

• Unique spine functional testing that delivers improved surgical outcomes 

• Robotic system for fabrication of nano-material based wound dressings, delivered on-demand, at the POC 

• Digital image acquisition, coupled with proprietary CAD decision-making algorithms, to provide an immediate/automated colposcopic evaluation 

• Cardiac assist device for patients in moderate/severe long-term heart failure 

• Catheter-based systems that will provide very rapid/selective hypothermia to various body organs and locations 

• Truly minimally invasive or open system utilizing a proprietary uni-axial screw at one-half the cost of poly-axial systems for all spine disorders 

• Non-invasive devices for the treatment of superficial venous disease 

• Medical devices that enable earlier detection/minimally invasive treatment of lung cancer 

• MRI-guided laser ablation system for targeted, minimally invasive, focal tumor therapy 

• System of products that will restore continence control to individuals with abdominal ostomies/eliminate the need for traditional ostomy pouching systems 

• Non-invasive/iontophoretic drug delivery system with broad applicability for treating serious ocular diseases 

• Reliable/accurate/solid-state laser system for customized treatment of many vision disorders 

• Cryotherapy to ablate diseased tissue 

• Non-invasive/convenient measurement and monitoring of human hydration status, using saliva as a sample 

• A sof