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3F Therapeutics, Inc
AorTech International plc
Arbor Surgical Technologies, Inc
ATS Medical, Inc
Axya Medical, Inc
CardioMend
Corazón Technologies, Inc
CoreValve S.A.
CryoLife, Inc
Edwards Lifesciences Corporation
Evalve, Inc
Medical Carbon Research Institute, LLC
Medtronic, Inc
NuMED, Inc
Sorin Group
St. Jude Medical, Inc
EXECUTIVE SUMMARY
OUS Heart Valves Treated by Location and Surgical Approach
OUS Heart Valve Prostheses and Product Markets
Suppliers of Heart Valve Prostheses and Repair Products
Percutaneous Heart Valve Technologies
Summary Exhibit 1: OUS Population, Valve Surgeries and Valves Treated, 2003-2010
Summary Exhibit 2: OUS Valves Treated by Location and Approach, 2003-2010
Summary Exhibit 3: OUS Valve Prostheses by Type, 2003-2010
Summary Exhibit 4: OUS Valve Products Market by Type, 2003-2010
Summary Exhibit 5: OSU Heart Valve Products by Type and Geography, Supplier Shares, 2004
Summary Exhibit 6: Percutaneous Heart Valve Technologies, Market Forecast, 2004-2010
1.0 OVERVIEW OF HEART VALVE DISEASE
1.1 Valve Types and Function
1.2 Role of Valves in Cardiac Cycle
1.3 Etiology of Heart Valve Disease
1.3.1 Rheumatic Heart Disease
1.3.2 Degenerative Valve Disorders
1.3.3 Functional Valve Disorders
1.3.4 Congenital Valve Disorders
1.3.4.1 Complex Congenital Defects
1.3.4.2 Bicuspid Aortic Valve Disease
1.3.5 Infective Endocarditis
1.4 Diagnosis of Heart Valve Disease
1.4.1 Auscultation
1.4.2 Electrocardiography
1.4.3 Chest X-Rays
1.4.4 Echocardiography
1.4.5 Coronary Angiography
1.4.6 Other Diagnostic Tools
1.5 Treatment of Heart Valve Disease
1.5.1 Medical Management
1.5.2 Surgical Intervention
1.5.2.1 Treatment of Multi-Valve Disease
1.5.2.2 Emerging Techniques
1.5.2.3 Concomitant CABG and Valve Surgery
1.5.2.4 Multi-Valve Surgery
1.5.2.5 Procedure Trends and Geographic Variations
1.5.3 Transcatheter Valve Repair and Replacement
1.6 Mortality
1.7 Epidemiology and Characteristics by Valve Type
1.7.1 Aortic Valve Disease
1.7.1.1 Aortic Stenosis
1.7.1.2 Aortic Valve Sclerosis
1.7.1.3 Aortic Valve Regurgitation
1.7.2 Acquired Mitral Valve Disease
1.7.2.1 Mitral Valve Stenosis
1.7.2.2 Mitral Valve Prolapse
1.7.2.3 Mitral Valve Regurgitation
Exhibit 1-1: The Four Heart Valves
Exhibit 1-2: Etiology of Valvular Disease
Exhibit 1-3: Major Congenital Heart Defects
Exhibit 1-4: ESC Indications for Urgent Valve Surgery for Endocarditis
Exhibit 1-5: Selected International Studies of Infective Endocarditis
Exhibit 1-6: Major Techniques Used to Diagnose Heart Valve Disease
Exhibit 1-7: Selected Investigations Used in ESC Heart Survey on Valvular Heart Disease, 2001
Exhibit 1-8: A Typical ECG Trace
Exhibit 1-9: Information Obtained with Other Diagnostic Approaches to Valvular Disease
Exhibit 1-10: Treatment Options for Heart Valve Disease
Exhibit 1-11: Use of Drug Therapy in Treatment of Valvular Disease
Exhibit 1-12: Death Rates from Ischemic Heart Disease in Selected Nations
Exhibit 1-13: Overview of Aortic Valve Diseases
Exhibit 1-14: Hemodynamic Implications of Reduction in Aortic Valve Area
Exhibit 1-15: Classification of Aortic Stenosis by Severity
Exhibit 1-16: Estimated Prevalence of Severe Aortic Stenosis in Major European Nations, 2004-2010
Exhibit 1-17: Estimated Prevalence of Severe Aortic Stenosis in Japan, 2004-2010
Exhibit 1-18: Comparison of Major Mitral Valve Diseases
Exhibit 1-19: Estimated Prevalence of Mitral Regurgitation in Major Nations of Europe, 2004-2010
Exhibit 1-20: Estimated Prevalence of Mitral Regurgitation in Japan, 2004-2010
2.0 SURGICAL VALVE REPLACEMENT
2.1 Surgical Approaches
2.1.1 Traditional Median Sternotomy
2.1.2 Minimally Invasive Approaches
2.1.2.1 Technique
2.1.2.2 Advantages
2.1.2.3 Limitations
2.1.2.4 Clinical Experience
2.1.2.5 Enabling Technologies
2.1.2.5.1 Adjunctive Surgical Technologies
2.1.2.5.2 New Tissue Valve Designs
2.1.2.5.3 Valve Suturing and Implantation Technologies
2.1.2.6 Conclusions
2.2 Valve Prostheses
2.2.1 Mechanical Valves
2.2.1.1 Designs
2.2.1.2 Materials
2.2.1.3 Advantages
2.2.1.4 Limitations
2.2.2 Xenograft Tissue Valves
2.2.2.1 Tissue Sources
2.2.2.2 Stented versus Stentless
2.2.2.3 Advantages
2.2.2.4 Limitations
2.2.3 Allograft Valves
2.3 Prosthetic Heart Valve Products
2.3.1 Mechanical Heart Valves
2.3.1.1 ATS Medical
2.3.1.2 Medical Carbon Research Institute
2.3.1.3 Medtronic
2.3.1.4 Roscardioinvest
2.3.1.5 St. Jude Medical
2.3.1.6 Sorin Group/CarboMedics
2.3.1.7 TTK Pharma Ltd
2.3.2 Tissue Heart Valves
2.3.2.1 CryoLife
2.3.2.2 Braile Biomedica
2.3.2.3 Edwards Lifesciences
2.3.2.3.1 Perimount Valves
2.3.2.3.2 Porcine Stented Valves
2.3.2.4 Kemerovo Cardiac Center
2.3.2.5 Medtronic
2.3.2.6 St. Jude Medical
2.3.2.6.1 St. Jude Products
2.3.2.6.2 Biocor Products
2.3.2.7 Shelhigh
2.3.2.8 Sorin Group
2.3.3 Allograft Valves
2.3.3.1 Cryopreservation
2.3.3.2 Sterilization
2.3.3.3 Suppliers
2.3.4 Emerging Prostheses Technologies
2.3.4.1 Autologous Tissue Valves
2.3.4.1.1 CardioMend
2.3.4.1.2 International Heart Institute and Nayang Technological University
2.3.4.1.3 Other Programs
2.3.4.2 New Tissue Valve Designs
2.3.4.2.1 Arbor Surgical Technologies
2.3.4.2.2 3F Therapeutics
2.3.4.2.3 ValveXchange
2.3.4.3 Tri-Leaflet Mechanical Heart Valves
2.3.4.3.1 AorTech International
2.3.4.3.2 Innovia LLC
2.3.4.3.3 Triflo Medical
2.3.4.4 Tissue-Engineered Valves
2.3.4.4.1 Advanced Tissue Sciences
2.3.4.4.2 CryoLife
2.3.4.4.3 Philogenesis
2.3.4.4.4 Tepha.
2.3.4.4.5 Georgia Institute of Technology/Emory Center
2.3.4.4.6 Other Institution-Based Programs
2.3.4.4.7 Challenges
2.3.4.4.8 Prospects for Tissue Engineered Heart Valves
2.3.5 Valve Suturing and Implantation Technologies
2.3.5.1 ANPA Medical
2.3.5.2 Arbor Surgical Technologies
2.3.5.3 Axya Medical
2.3.5.4 Medtronic
2.3.5.5 Teleflex Medical
Exhibit 2-1: Comparison of Surgical Approaches for Valve Replacement
Exhibit 2-2: Potential Advantages of Minimally Invasive Valve Replacement
Exhibit 2-3: Potential Drawbacks of Minimally Invasive Valve Replacement
Exhibit 2-4: Selected International Studies of Minimally Invasive Valve Surgery
Exhibit 2-5: Selected Enabling Technologies for Minimally Invasive Valve Surgery
Exhibit 2-6: Selected Adjunctive Surgical Technologies Designed to Facilitate Valve Surgery, 2005
Exhibit 2-7: Design Criteria for Ideal Prosthetic Heart Valve
Exhibit 2-8: Comparison of Mechanical, Tissue and Allograft Heart Valves
Exhibit 2-9: Mechanical Valve Designs
Exhibit 2-10: Prosthetic Tissue Valve Materials and Configurations
Exhibit 2-11: Selected Mechanical Heart Valves, 2005
Exhibit 2-12: Selected Xenograft Tissue Valves, 2005
Exhibit 2-13: Selected Stented Tissue Valves
Exhibit 2-14: Selected Stentless Tissue Valves
Exhibit 2-15: Selected Emerging Surgical Valve Technologies, 2005
Exhibit 2-16: Selected Autologous Tissue Valve Technologies, 2005
Exhibit 2-17: Selected Autologous Pericardial Valves
Exhibit 2-18: Selected Valve Technologies Facilitating Minimally Invasive Implantation, 2005
Exhibit 2-19: 3F Therapeutic Heart Valves
Exhibit 2-20: Selected Tri-Leaflet Mechanical Valve Technologies, 2005
Exhibit 2-21: Comparison of Cell Sources for Tissue-Engineered Heart Valves
Exhibit 2-22: Selected Heart Valve Tissue Engineering Programs, 2005
Exhibit 2-23: Challenges to Commercialization of Tissue Engineering Products
Exhibit 2-24: Selected Valve Suturing and Advanced Implantation Technologies, 2005
Exhibit 2-25: AxyaLoop versus Traditional Knotted Suture
Exhibit 2-26: Cinch Advanced Implantation System versus Standard Holder
Exhibit 2-27: Teleflex Medical's Valve Suturing Technologies
3.0 SURGICAL VALVE REPAIR
3.1 Techniques
3.2 Operative Approaches
3.2.1 Traditional Open Heart Surgery
3.2.2 Direct Vision Minimal Access Heart Valve Repair
3.2.3 Video-Assisted Endoscopic Valve Repair
3.2.4 Robotically-Assisted Mitral Valve Repair
3.2.5 Beating Heart Valve Repair
3.2.5.1 Edwards Lifesciences
3.2.5.2 Medtronic
3.2.6 Aortic Valve Sparing Surgery
3.3 Annuloplasty Rings
3.3.1 Designs
3.3.2 Traditional Products
3.3.2.1 CarboMedics/Sorin Group
3.3.2.2 Edwards Lifesciences
3.3.2.3 Getinge AB
3.3.2.4 Koehler Chemie
3.3.2.5 Medtronic
3.3.2.6 St. Jude Medical
3.3.2.7 Shelhigh Inc
3.3.3 Emerging Technologies
3.3.3.1 Corazón Technologies
3.3.3.2 CoroNeo
3.3.3.3 Medtentia AB
3.3.3.4 MitralSolutions
3.3.3.5 Myocor
3.3.3.6 QuantumCor
Exhibit 3-1: Heart Valve Surgical Repair Techniques
Exhibit 3-2: Current and Emerging Surgical Approaches for Valve Repair
Exhibit 3-3: Edwards Lifesciences' LifeStitch Surgical Valve Repair Technology
Exhibit 3-4: Design Characteristics of Annuloplasty Rings
Exhibit 3-5: Selected Annuloplasty Rings, 2005
Exhibit 3-6: Selected Emerging Valve Repair Technologies, 2005
Exhibit 3-7: Corazón Technologies Stopped Heart Aortic Valve Repair System
Exhibit 3-8: Myocor's Coapsys Annuloplasty System
4.0 OUS SURGICAL VALVE PRODUCT MARKETS
4.1 European Heart Valve Market
4.1.1 Major Europe
4.1.1.1 Germany
4.1.1.2 France
4.1.1.3 Italy
4.1.1.4 Spain
4.1.1.5 United Kingdom
4.1.1.6 Benelux
4.1.2 Other Europe
4.2 Japan
4.3 Rest of World (ROW)
Exhibit 4-1: OUS Heart Valve Procedures, Products and Markets, 2003-2010
Exhibit 4-2: European Valve Procedures, Products & Markets, 2003-2010
Exhibit 4-3: European Heart Valve Prostheses and Product Markets by Region, 2003-2010
Exhibit 4-4: European Heart Valve Products, Supplier Shares, 2004
Exhibit 4-5: Major Europe, Heart Valve Procedures, Products and Markets, 2003-2010
Exhibit 4-6: Germany, Trend in Cardiac Surgery Resources and Procedures, 1997-2004
Exhibit 4-7: Germany, Heart Valve Procedures and Market, 2003-2010
Exhibit 4-8: France, Heart Valve Procedures and Market, 2003-2010
Exhibit 4-9: Italy, Heart Valve Procedures and Market, 2003-2010
Exhibit 4-10: Spain, Valve Surgery Data, 2001-2003
Exhibit 4-11: Spain, Heart Valve Procedures and Market, 2003-2010
Exhibit 4-12: National Health Service, Main Operations, 2000-2004
Exhibit 4-13: National Health Service, Total Operations, 2000-2004
Exhibit 4-14: United Kingdom, Heart Valve Procedures and Markets, 2003-2010
Exhibit 4-15: Benelux, Heart Valve Procedures and Markets, 2003-2010
Exhibit 4-16: Other Europe, Heart Valve Procedures and Markets, 2003-2010
Exhibit 4-17: Japan, Heart Valve Procedures by Location, 1996-2004
Exhibit 4-18: Japan, Heart Valve Procedures by Location, Approach & Prosthesis Type, 1996-2004
Exhibit 4-19: Japan, Heart Valve Procedures and Markets, 2003-2010
Exhibit 4-20: Japan Heart Valve Products, Supplier Shares, 2004
Exhibit 4-21: Rest of World, Heart Valve Procedures, Products and Markets, 2003-2010
Exhibit 4-22: Rest of World Heart Valve Products, Supplier Shares, 2004
5.0 TRANSCATHETER VALVE TECHNOLOGIES
5.1 Percutaneous Balloon Valvuloplasty
5.1.1 Clinical Applications
5.1.2 Procedure
5.1.3 Comparison of Available Techniques
5.1.3.1 Single vs. Double Balloon Techniques for Mitral Stenosis
5.1.3.2 Metallic Valvulotome
5.1.4 Clinical Outcomes
5.1.5 Products
5.1.5.1 Balt Extrusion
5.1.5.2 NuMED
5.1.5.2.1 Tyshak
5.1.5.2.2 Z-Med
5.1.5.2.3 COEfficient
5.1.5.2.4 Nucleus
5.1.5.2.5 Multi-Track
5.1.5.3 Toray
5.1.6 Procedures
5.1.7 Market Analysis
5.2 Percutaneous Valve Repair and Replacement
5.2.1 Rationale
5.2.2 Approaches
5.2.2.1 Percutaneous Valve Repair
5.2.2.1.1 Edge-To-Edge
5.2.2.1.2 Annuloplasty
5.2.2.1.3 Other Approaches
5.2.2.2 Percutaneous Valve Replacement
5.2.2.2.1 Valve Design Criteria
5.2.2.2.2 Implantation Approaches
5.2.2.2.3 Obstacles to Percutaneous Valve Replacement
5.2.3 Specialists Performing
5.2.4 Products and Suppliers
5.2.4.1 Advanced Bio Prosthetic Surfaces
5.2.4.2 Ample Medical
5.2.4.3 Cardiac Dimensions
5.2.4.4 Cook Biotech
5.2.4.5 Corazón Technologies
5.2.4.6 CoreValve
5.2.4.7 Direct Flow Medical
5.2.4.8 Edwards Lifesciences
5.2.4.8.1 LifeStitch Edge-To-Edge
5.2.4.8.2 Coronary Sinus Annuloplasty
5.2.4.8.3 Aortic Valve Replacement
5.2.4.9 Endoluminal Technology Research
5.2.4.10 Evalve
5.2.4.11 3F Therapeutics
5.2.4.12 Heart Leaflet Technologies
5.2.4.13 University of Kiel
5.2.4.14 Medtronic/NuMED
5.2.4.15 Mitralign
5.2.4.16 QuantumCor
5.2.4.17 Sadra Medical
5.2.4.18 ValveXchange
5.2.4.19 Viacor
5.2.5 Procedure Trends
5.2.6 Market Forecast
Exhibit 5-1: Suggested Indications for Balloon Aortic Valvuloplasty in Adults
Exhibit 5-2: Selected Studies of PBV for Mitral Stenosis
Exhibit 5-3: Reported Complications in Aortic Valvuloplasty Registries
Exhibit 5-4: Selected Studies of PBV for Aortic Stenosis
Exhibit 5-5: A Thirty-Year Experience with Aortic Valve Stenosis
Exhibit 5-6: Selected Percutaneous Balloon Valvuloplasty Catheters, 2005
Exhibit 5-7: Percutaneous Balloon Valvuloplasty, Procedure and Market Forecast, 2004-2010
Exhibit 5-8: Percutaneous Valvuloplasty Catheters, Supplier Shares, 2004
Exhibit 5-9: Percutaneous Approaches to Heart Valve Disease Management
Exhibit 5-10: Design Criteria for Percutaneous Heart Valve
Exhibit 5-11: Major Approaches to Percutaneous Aortic Valve Replacement
Exhibit 5-12: Potential Challenges for Percutaneous Valve Replacement
Exhibit 5-13: Selected Percutaneous Valve Repair and Replacement Programs, 2005
Exhibit 5-14: Advanced Bio Prosthetic Surfaces’ PercValve System
Exhibit 5-15: Ample Medical’s Percutaneous Septal Sinus Shortening (PS³) System
Exhibit 5-16: The Cook-SIS Valve
Exhibit 5-17: Corazón Technologies' BHAVR System (Prototype)
Exhibit 5-18: CoreValve's ReValving System
Exhibit 5-19: Edwards Lifesciences' Percutaneous Valve Technologies
Exhibit 5-20: Clinical Outcomes of the Cribier-Edwards Valve (I-REVIVE Registry)
Exhibit 5-21: Endoluminal Technology Research Valve
Exhibit 5-22: Evalve's MitraClip System
Exhibit 5-23: 3F Therapeutics' Transcatheter Valve Technologies
Exhibit 5-24: Medtronic/NuMED Percutaneous Valve
Exhibit 5-25: Mitralign Mitral Valve Annuloplasty System
Exhibit 5-26: Viacor Percutaneous Transvenous Mitral Annuloplasty Technology
Exhibit 5-27: Projected Rollout of Selected Percutaneous Valve Programs
Exhibit 5-28: Transcatheter Valve Repair and Replacement, Procedure Forecast, 2004-2010
Exhibit 5-29: Transcatheter Valve Repair and Replacement Products, Market Forecast, 2006-2010
6.0 COUNTRY HEALTH CARE PROFILES
6.1 Overview of European Health Care
6.1.1 Health Care Spending and Reform
6.1.2 Health Care Facilities and Manpower
6.1.3 Reimbursement
6.1.4 Impact of the European Community
6.1.4.1 EC Directives
6.1.4.2 Pricing
6.1.5 National Profiles
6.1.5.1 Germany
6.1.5.1.1 Healthcare Systemand Resources
6.1.5.1.2 DRG System
6.1.5.1.3 Proposed Legislation
6.1.5.1.4 Cardiac Procedures and Resources
6.1.5.2 France
6.1.5.2.1 Health Care System and Resources
6.1.5.2.2 Health Care Spending
6.1.5.2.3 Health Care Administration
6.1.5.2.4 Product Regulation
6.1.5.2.5 Product Reimbursement
6.1.5.2.6 French Medical Device Market
6.1.5.2.7 Cardiac Procedures and Resources
6.1.5.3 United Kingdom
6.1.5.3.1 Health Care Statistics Overview
6.1.5.3.2 National Health Service
6.1.5.3.3 Medical Products Regulation
6.1.5.3.4 Health Care Reforms
6.1.5.3.5 U.K. Medical Device Market
6.1.5.3.6 Cardiac Procedures and Resources
6.1.5.4 Italy
6.1.5.4.1 Emerging Private Sector
6.1.5.4.2 Product Issues
6.1.5.4.3 Cardiac Procedures
6.1.5.5 Spain
6.1.5.5.1 Health Care Funding and Delivery
6.1.5.5.2 Health Care Resources
6.1.5.5.3 Ambulatory Care Reforms
6.1.5.5.4 Product Issues
6.1.5.5.5 Cardiac Resources and Procedures
6.1.5.6 Belgium
6.1.5.6.1 Health Care Spending and Administration
6.1.5.6.2 Product Regulation and Reimbursement
6.1.5.6.3 Health Care Resources
6.1.5.6.4 Cardiac Procedures
6.1.5.7 The Netherlands
6.1.5.7.1 Health Care Overview
6.1.5.7.2 Health Care Resources
6.1.5.7.3 Health Care Spending and Programs
6.1.5.7.4 Health Care Administration
6.1.5.7.5 Product Issues
6.1.5.7.6 Cardiac Resources and Procedures
6.2 Other Europe
6.3 Japan
6.3.1 Structure of Health Insurance System
6.3.2 Health Care Spending and Legislation
6.3.3 Health Care Facilities
6.3.4 Health Manpower
6.3.5 Medical Device Market
6.3.6 Product Regulation and Reimbursement
6.3.7 Cardiovascular Resources and Procedures
6.4 Overview of Asia-Pacific Health Care (ex Japan)
6.4.1 Health Care Spending
6.4.2 Health Care Resources
6.4.3 Selected Country Overviews
6.4.3.1 China
6.4.3.2 India
6.4.3.3 Malaysia
6.4.3.4 Philippines
6.4.3.5 Singapore
6.4.3.6 South Korea
6.4.3.7 Thailand
6.5 Overview of Latin American Health Care
6.5.1 Brazil
6.5.2 Mexico
6.5.3 Argentina
Exhibit 6-1: Health Care Expenditures by Country, 2003
Exhibit 6-2: Physicians by Country, 2003
Exhibit 6-3: Acute Care Hospital Beds and Utilization, 2003
Exhibit 6-4: Germany, Health Care Profile
Exhibit 6-5: Germany, Health Expenditures as Share of GDP, 1998-2003
Exhibit 6-6: Distribution of Statutory Health Insurance Expenditures, 2003
Exhibit 6-7: Germany, Cardiac Resources and Procedures
Exhibit 6-8: France, Health Care Profile
Exhibit 6-9: France, Health Expenditures as Share of GDP, 1998-2003
Exhibit 6-10: France, Reimbursement for Heart Valve Procedures and Products
Exhibit 6-11: United Kingdom, Health Care Profile
Exhibit 6-12: United Kingdom, Health Expenditures as Share of GDP, 1998-2003
Exhibit 6-13 : Cardiac Surgeries, Total Operations, England, 2000-2004
Exhibit 6-14: Italy, Health Care Profile
Exhibit 6-15: Italy, Health Expenditures as Share of GDP, 1998-2003
Exhibit 6-16: Italy, Distribution of Cardiac Surgeries, 2003
Exhibit 6-17: Health Care Profile, Spain
Exhibit 6-18: Spain, Health Expenditures as Share of GDP, 1998-2003
Exhibit 6-19: Spain, Trend in Cardiac Surgeries, 2001-2003
Exhibit 6-20: Belgium, Health Care Profile
Exhibit 6-21: Belgium, Health Expenditures as Share of GDP, 1998-2003
Exhibit 6-22: Belgium, Cardiac Surgical Procedures, 2001-2002
Exhibit 6-23: The Netherlands, Health Care Profile
Exhibit 6-24: Annual Trend in Dutch Health Expenditures as Share of GDP
Exhibit 6-25: Selected Other European Nations, Health Care Indicators
Exhibit 6-26: Overview of Japanese Health Insurance Programs
Exhibit 6-27: Comparison of Three Major Japanese Health Insurance Programs
Exhibit 6-28: Japan, Health Expenditures as Share of GDP, 1998-2003
Exhibit 6-29: Overview of Japan’s Health Facilities and Personnel
Exhibit 6-30: Japan, Cardiac Operations by Major Type, 1997-2003
Exhibit 6-31: Health Care Indicators for Selected Asia Pacific Nations
Exhibit 6-32: Health Care Resources in Selected Asia-Pacific Nations
Exhibit 6-33: Per Capita Mortality Rates by Type Among Selected Latin American Regions
Exhibit 6-34: Per Capita Health Care Resources in Selected Latin American Regions
Exhibit 6-35: National Health Care Spending in Latin America, 2004
7.0 COMPANY PROFILES
7.1 AorTech International plc
7.2 ATS Medical, Inc
7.3 Arbor Surgical Technologies, Inc
7.4 Axya Medical, Inc
7.5 CardioMend
7.6 Corazón Technologies, Inc
7.7 CoreValve S.A.
7.8 CryoLife, Inc
7.9 Edwards Lifesciences Corporation
7.10 Evalve, Inc
7.11 Medical Carbon Research Institute, LLC
7.12 Medtronic, Inc
7.13 NuMED, Inc
7.14 St. Jude Medical, Inc
7.15 Sorin Group
7.16 3F Therapeutics, Inc