This report covers the novel drug-coated balloon and drug-eluting stent technologies that are expected to trigger a paradigm shift in treatment of advanced peripheral artery disease-particularly lower extremity occlusions-driving the development of a new multi-billion dollar market. Also covered in the report are revascularization-enabling peripheral atherectomy systems and dedicated refractory CTO crossing devices that are projected to see above-average growth through 2019.
Aachen Resonance
Abbott Vascular (Abbott Laboratories)
Avinger Medical Technologies
Bard Peripheral (C.R. Bard)
Bayer HealthCare (Bayer AG)
Biosensors International
Biotronik
Boston Scientific
Cardionovum
Cardiovascular Systems
Cook Medical
Cordis (Johnson & Johnson)
Covidien
Eurocor (Opto Circuits)
iVascular
Medtronic
Medtronic plc
Spectranetics
EXECUTIVE SUMMARY
Symptomatic Peripheral Artery Disease
Interventions by Major Type
Global Product Markets
Product Markets by Major Geography
Major Suppliers
Summary Exhibit 1: Estimated Prevalence of Symptomatic Peripheral Artery Disease by Major Geography, 2013-2019
Summary Exhibit 2: Peripheral Angioplasty Procedures by Major Geography, 2013 – 2019
Summary Exhibit 3: Distribution of Global PTA Procedures by Lesion Location and Major Procedure Type, 2013-2019
Summary Exhibit 4: Global Market for Targeted Devices by Type, 2013-2019
Summary Exhibit 5: Global Market for Four Targeted Products by Major Geography, 2013-2019
Summary Exhibit 6: Global Market for Peripheral Drug-Coated Balloons by Major Geography, 2013-2019
Summary Exhibit 7: Global Market for Peripheral Drug-Eluting Stents by Major Geography, 2013-2019
Summary Exhibit 8: Global Market for Peripheral Atherectomy Devices, 2013-2019
Summary Exhibit 9: Global Market for Dedicated Refractory CTO Devices, 2013-2019
Summary Exhibit 10: Market for Four Targeted Products, United States, 2013-2019
Summary Exhibit 11: Market for Four Targeted Products, Major Europe, 2013-2019
Summary Exhibit 12: Market for Four Targeted Products, Major Asia-Pacific, 2013-2019
Summary Exhibit 13: Market for Four Targeted Products, Rest of World, 2013-2019
Summary Exhibit 14: Leading Suppliers of Four Targeted Products, 2014
1.0 ETIOLOGY, EPIDEMIOLOGY & PROCEDURES
1.1 Overview of Peripheral Vascular Infrastructure
1.2 Peripheral Arterial Disease
1.2.1 Symptoms
1.2.2 Causes
1.2.3 Risk Factors
1.2.4 Prevalence
1.3 Critical Limb Ischemia
1.3.1 Causes
1.3.2 Disease Progression
1.3.3 Disease Management and Interventional Therapy
1.3.4 Incidence of CLI and Limb Amputation
1.4 Chronic Total Occlusions
1.4.1 Incidence
1.4.2 Treatment Regimens
1.5 PTA Procedures
1.5.1 Peripheral Angioplasties by Location
1.5.2 Peripheral Angioplasties by Type
Exhibit 1-1: Major Lower Extremity Arteries
Exhibit 1-2: Normal versus Atherosclerotic Peripheral Artery
Exhibit 1-3: Estimated Prevalence of Symptomatic Peripheral Artery Disease by Major Geography, 2013-2019
Exhibit 1-4: Overview of Peripheral Artery Disease and Critical Limb Ischemia
Exhibit 1-5: Estimated Incidence of Critical Limb Ischemia and Limb Amputation by Selected Geographies, 2013-2019
Exhibit 1-6: Development of a Chronic Total Occlusion
Exhibit 1-7: Peripheral Angioplasty Procedures by Major Geography, 2013–2019
Exhibit 1-8: Distribution of PTA Procedures by Lesion Location, United States, 2013-2019
Exhibit 1-9: Distribution of PTA Procedures by Lesion Location, Major Europe, 2013-2019
Exhibit 1-10: Distribution of PTA Procedures by Lesion Location, Major Asia-Pacific, 2013-2019
Exhibit 1-11: Distribution of PTA Procedures by Lesion Location, Rest of World, 2013-2019
Exhibit 1-12: Distribution of Global PTA Procedures by Lesion Location, 2013-2019
Exhibit 1-13: Distribution of PTA Procedures by Type, United States, 2013-2019
Exhibit 1-14: Distribution of PTA Procedures by Type, Major Europe, 2013-2019
Exhibit 1-15: Distribution of PTA Procedures by Type, Major Asia-Pacific, 2013-2019
Exhibit 1-16: Distribution of PTA Procedures by Type, Rest of World, 2013-2019
Exhibit 1-17: Distribution of Global PTA Procedures by Type, 2013-2019
2.0 PRODUCTS AND TECHNOLOGIES
2.1 Peripheral Drug-Coated Balloons
2.1.1 Drug Delivery Methods
2.1.2 Balloon Coating Technologies
2.1.3 Carrier Excipients
2.1.4 Products
2.1.4.1 Aachen Resonance
2.1.4.2 Bard Peripheral Vascular
2.1.4.3 Bayer AG
2.1.4.4 Biotronik
2.1.4.5 Biosensors International
2.1.4.6 Boston Scientific
2.1.4.7 Cardionovum
2.1.4.8 Cook Medical
2.1.4.9 Eurocor
2.1.4.10 iVascular
2.1.4.11 Medtronic plc
2.1.4.12 Spectranetics
2.1.5 Second Generation DCB Technologies under Development
2.1.6 Clinical Experience with Drug-Coated Balloons
2.2 Peripheral Drug-Eluting Stents
2.2.1 Anti-Restenosis Drugs
2.2.2 Products
2.2.2.1 Abbott Vascular
2.2.2.2 Alvimedica Medical Technologies
2.2.2.3 Boston Scientific
2.2.2.4 Cook Medical
2.2.2.5 Johnson & Johnson Cordis
2.2.3 Clinical Experience with Peripheral DES
2.2.3.1 SIROCCO I and II
2.2.3.2 Zilver PTX Trial
2.2.3.3 ACHILLES Trial
2.2.3.4 DESTINY Trial
2.3 Peripheral Debulking Technologies
2.3.1 Atherectomy Systems
2.3.2 Atherotomy Devices
2.4 Dedicated Refractory CTO Crossing Devices
2.4.1 Products
2.4.2 Clinical Experience
Exhibit 2-1: Selected Peripheral Drug-Coated Balloon (DCB) Angioplasty Systems, 2015
Exhibit 2-2: Performance Data from Clinical Trials of Drug-Coated Balloons versus PTA in Symptomatic Patients with Superficial Femoral Artery (SFA) Occlusiions
Exhibit 2-3: Performance Data from Clinical Trials of Drug-Coated Balloons versus Peripheral Transluminal Angioplasty in Symptomatic Critical Limb Ischemia Patients with Below-the-Knee Arterial Occlusions
Exhibit 2-4: Selected Peripheral Drug-Eluting Stent Technologies, 2015
Exhibit 2-5: Performance Data from Clinical Trials of Drug-Coated Stents versus Control in Patients with Symptomatic Critical Limb Ischemia and Superficial Femoral Artery (SFA) and Below-the-Knee (BTK) Occlusions
Exhibit 2-6: Overview of Peripheral Debulking Technologies
Exhibit 2-7: Selected Peripheral Atherectomy Technologies, 2015
Exhibit 2-8: Selected Atherotomy Technologies, 2015
Exhibit 2-9: Selected Crossing Support Catheters, 2015
Exhibit 2-10: Selected Dedicated Refractory CTO Devices, 2015
Exhibit 2-11: Selected Trials of Dedicated Peripheral Refractory CTO Technologies
3.0 PROCEDURES & MARKETS
3.1 Drug-Coated Balloons
3.1.1 Procedures and Markets by Geography
3.1.2 Competitive Analysis
3.2 Drug-Eluting Stents
3.2.1 Procedures and Markets by Geography
3.2.2 Competitive Analysis
3.3 Atherectomy Devices
3.3.1 Procedures and Markets by Geography
3.3.2 Competitive Analysis
3.4 Dedicated Refractory CTO Crossing Devices
3.4.1 Procedures and Markets by Geography
3.4.2 Competitive Analysis
Exhibit 3-1: Global Peripheral Drug-Coated Balloon , Procedures and Market, 2013-2019
Exhibit 3-2: Peripheral Drug-Coated Balloon Angioplasty, United States, Procedures and Market, 2013-2019
Exhibit 3-3: Peripheral Drug-Coated Balloon Angioplasty, Major Europe, Procedures and Market, 2013-2019
Exhibit 3-4: Peripheral Drug-Coated Balloon Angioplasty, Major Asia-Pacific, Procedures and Market, 2013-2019
Exhibit 3-5: Peripheral Drug-Coated Balloon Angioplasty, Rest of World, Procedures and Market, 2013-2019
Exhibit 3-6: Peripheral Drug-Coated Balloons, Estimated Supplier Shares, 2014
Exhibit 3-7: Global Peripheral Drug-Eluting Stents, Procedures and Markets, 2013-2019
Exhibit 3-8: Peripheral Drug-Eluting Stents, United States, Procedures and Markets, 2013-2019
Exhibit 3-9: Peripheral Drug-Eluting Stents, Major Europe, Procedures and Markets, 2013-2019
Exhibit 3-10: Peripheral Drug-Eluting Stents, Major Asia-Pacific, Procedures and Markets, 2013-2019
Exhibit 3-11: Peripheral Drug-Eluting Stents, Rest of World, Procedures and Markets, 2013-2019
Exhibit 3-12: Peripheral Dug-Eluting Stents, Estimated Supplier Shares, 2014
Exhibit 3-13: Global Peripheral Atherectomy, Procedures and Markets, 2013-2019
Exhibit 3-14: Peripheral Atherectomy, United States, Procedures and Markets, 2013-2019
Exhibit 3-15: Peripheral Atherectomy, Major Europe, Procedures and Markets, 2013-2019
Exhibit 3-16: Peripheral Atherectomy, Major Asia-Pacific, Procedures and Markets, 2013-2019
Exhibit 3-17: Peripheral Atherectomy, Rest of World, Procedures and Markets, 2013-2019
Exhibit 3-18: Peripheral Atherectomy, Estimated Supplier Shares, 2014
Exhibit 3-19: Global Peripheral Refractory CTO Crossing, Procedures and Markets, 2013-2019
Exhibit 3-20: Peripheral Refractory CTO Crossing, United States, Procedures and Markets, 2013-2019
Exhibit 3-21: Peripheral Refractory CTO Crossing, Major Europe, Procedures and Markets, 2013-2019
Exhibit 3-22: Peripheral Refractory CTO Crossing, Major Asia-Pacific, Procedures and Markets, 2013-2019
Exhibit 3-23: Peripheral Refractory CTO Crossing, Rest of World, Procedures and Markets, 2013-2019
Exhibit 3-24: Dedicated Peripheral CTO Crossing Devices, Supplier Shares, 2014
4.0 COMPANY PROFILES
4.1 Aachen Resonance
4.2 Abbott Vascular (Abbott Laboratories)
4.3 Avinger Medical Technologies
4.4 Bard Peripheral (C.R. Bard)
4.5 Bayer HealthCare (Bayer AG)
4.6 Biosensors International
4.7 Biotronik
4.8 Boston Scientific
4.9 Cardionovum
4.10 Cardiovascular Systems
4.11 Cook Medical
4.12 Cordis (Johnson & Johnson)
4.13 Eurocor (Opto Circuits)
4.14 iVascular
4.15 Medtronic plc
4.15.1 Covidien
4.15.2 Medtronic
4.16 Spectranetics
5.0 MAJOR COUNTRY PROFILES
5.1 United States
5.2 Major Western Europe
5.2.1 Overview of European Healthcare
5.2.1.1 Healthcare Spending and Reforms
5.2.1.2 Healthcare Facilities and Manpower
5.2.1.3 Reimbursement
5.2.1.4 Impact of the European Union
5.2.2 National Healthcare Profiles
5.2.2.1 France
5.2.2.2 Germany
5.2.2.3 Italy
5.2.2.4 Spain
1.2.2.5 United Kingdom
5.3 Major Asia-Pacific
5.3.1 China
5.3.2 India
5.3.3 Japan
Exhibit 5-1: United States, Selected Health Care Indicators
Exhibit 5-2: France, Selected Health Care Indicators
Exhibit 5-3: Germany, Selected Health Care Indicators
Exhibit 5-4: Italy, Selected Health Care Indicators
Exhibit 5-5: Spain, Selected Health Care Indicators
Exhibit 5-6: United Kingdom, Selected Health Care Indicators
Exhibit 5-7: China, Selected Health Care Indicators
Exhibit 5-8: India, Selected Health Care Indicators
Exhibit 5-9: Japan, Selected Health Care Indicators