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Worldwide Markets and Emerging Technologies for Tissue Engineering and Regenerative Medicine

262 Pages | 78 Exhibits | Forecasts Through 2013
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Overview

The tissue engineering and regenerative medicine market first emerged in the mid-1990's with the introduction of products for wound care and orthopaedic applications. The market has since expanded substantially, and approached $1.5 billion in 2008. The market is projected to grow at a 16.2% compound annual rate from 2008 through 2013, approaching $3.2 billion by 2013. This in-depth new market and technology report analyzes the following key topics:
  • Tissue engineering and regenerative medicine technologies
  • Market analysis for cardiovascular applications of tissue engineering and regenerative medicine, including heart valve repair and replacement, myocardial tissue regeneration for heart failure, and applications in peripheral vascular and coronary artery disease
  • Orthopaedic applications and market analysis, including cartilage repair and replacement, bone repair, ligament and tendon repair and replacement, joint repair, and spinal disc repair
  • Applications in neurology including repair of spinal cord injury, Parkinson's disease, epilepsy, multiple sclerosis, peripheral nerve injury, stroke and CNS disorders
  • Market analysis for applications in urology including treatment of urinary incontinence, bladder repair, ureter and urethra repair, penile reconstruction and treatment of erectile dysfunction, and treatment of vesicoureteral reflux
  • Applications in organ regeneration including analysis of existing organ supplementation markets and technologies and development-stage technologies for liver, kidney, heart, pancreas, bone marrow, and small intestine replacement
  • Market analysis for applications in wound management, skin repair, and skin ulcer treatment
  • Current and forecast market size, pricing trends, and analysis of competitive factors
  • Key business transactions, competitor strategies, and technology portfolio analysis
  • Detailed coverage of 227 companies plus in-depth competitor profiles of top 40

Table of Contents

EXECUTIVE SUMMARY

Market Summary and Forecast
Growth Projections by Market Segment
Major Opportunities in International Markets
Large and Expanding Potential Markets
High  Growth of Potential Markets in Multiple Segments
Key Companies Include Leading Medical Device and Biotechnology Suppliers and Emerging Competitors	

Exhibit ES-1: Worldwide Market for Tissue Engineering and Regenerative Medicine Products, 2007-2013
Exhibit ES-2: Worldwide Market for Tissue Engineering and Regenerative Medicine Products by Region, 2001-2013
Exhibit ES-3: Target Procedures and Potential Markets by Segment
Exhibit ES-4: Target Procedure Volume by Region
Exhibit ES-5: Potential Market Segment Growth Comparison
Exhibit ES-6: 2008 Tissue Engineering and Regenerative Medicine Suppliers' Sales and Market Share

1. TISSUE ENGINEERING AND REGENERATIVE MEDICINE TECHNOLOGIES

1.1 Biomaterials Technologies
	1.1.1 Synthetic Materials
	1.1.2 Biologically Derived Materials
	1.1.3 Genetically Engineered Materials
1.2 Stem Cell Technologies
	1.2.1 Stem Cell Sources
	1.2.2 Stem Cell Extraction Techniques
	1.2.3 Stem Cell Expansion
	1.2.4 Stem Cell Delivery
	1.2.5 Existing and Development-Stage Stem Cell Products
1.3 Cell Culture Technologies
1.4 Immunopassivation and Immunomodulation
	1.4.1 Chimeric Immunopassivation
	1.4.2 Immunomodulation
	1.4.3 Cell Encapsulation

Exhibit 1.1: Synthetic Materials Used in Tissue Engineering and Regenerative Medicine
Exhibit 1.2: Biologically Derived Materials Used in Tissue Engineering and Regenerative Medicine
Exhibit 1.3: Genetic Engineering Technologies for Tissue Engineering and Regenerative Medicine
Exhibit 1.4: Stem Cell Sources
Exhibit 1.5: Diseases Treated with Umbilical Cord Blood Stem Cell Transplants
Exhibit 1.6: Materials Used in Stem Cell Culture
Exhibit 1.7: Stem Cell Collection Products for Hematopoetic Stem Cell Transplantation
Exhibit 1.8: Clinical Trials Involving Stem Cell Therapy

2. CARDIOVASCULAR APPLICATIONS OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

2.1 Cardiovascular Disease Incidence and Prevalence
2.2 Cardiovascular Applications and Market Potential
	2.2.1 Heart Valve Repair and Replacement
	2.2.2 Heart Failure and Myocardial Tissue Regeneration
	2.2.3 Applications in Peripheral Vascular Disease
	2.2.4 Applications in Coronary Artery Disease
2.3 Market Forecast for Cardiovascular Applications
2.4 Cardiovascular Market Drivers and Limiters
2.5 Leading Companies in Cardiovascular Tissue Engineering and Regenerative Medicine

Exhibit 2.1:  Worldwide Deaths by Cause
Exhibit 2.2:  Worldwide Incidence and Prevalence of Cardiovascular Disease by Region
Exhibit 2.3:  U.S. Trends in Congestive Heart Failure and Heart Valve Disorders
Exhibit 2.4:  Proportion of Patients with Heart Valve Disorders Treated with Existing Valve Repair and Replacement Devices in the U.S.
Exhibit 2.5:  Trends in Heart Transplants and Deaths from Heart Failure in the U.S.
Exhibit 2.6:  Worldwide Target Market for Cardiovascular Applications by Segment
Exhibit 2.7:  Worldwide Target Procedures for Cardiovascular Applications by Region and Segment, 2007
Exhibit 2.8:  Worldwide Target Procedures and Patients for Tissue-Engineered Coronary Artery Bypass Grafts by Region, 2002-2007
Exhibit 2.9:  Worldwide Target Procedures for Tissue-Engineered Heart Valves by Region, 2002-2007
Exhibit 2.10: Worldwide Target Procedures for Myocardial Tissue Regeneration in Heart Failure Therapy by Region, 2002-2007
Exhibit 2.11: Worldwide Target Procedures for Tissue-Engineered Peripheral Vascular Bypass Grafts by Region, 2002-2007
Exhibit 2.12: Worldwide Target Procedures for Tissue-Engineered Dialysis Access Shunts by Region, 2002-2007
Exhibit 2.13: Worldwide Target Procedures for Regenerative Medicine-Based Heart Angiogenesis Therapy by Region, 2002-2007
Exhibit 2.14: Worldwide Target Procedures for Cardiovascular Applications of Tissue Engineering and Regenerative Medicine by Region, 2002-
                     2007
Exhibit 2.15: Leading Companies in Cardiovascular Tissue Engineering

CHAPTER 3: ORTHOPAEDIC APPLICATIONS AND MARKETS

3.1 Orthopaedic Disease Incidence and Existing Therapies
	3.1.1 Bone Fractures/Bone Repair and Replacement
	3.1.2 Cartilage Degeneration and Repair
		3.1.2.1 Osteochondral Allografts
		3.1.2.2 Osteochondral Autograft Transfer System and Mosaicplasty
		3.1.2.3 Autologous Chondrocyte Transplantation
		3.1.2.4 Matrix-induced Autologous Chondrocyte Implantation
		3.1.2.5 High Tibial Osteotomy
	3.1.3 Meniscus Defects and Repair
	3.1.4 Ligament and Tendon Injuries and Repair
	3.1.5 Joint Degeneration and Destruction
	3.1.6 Spinal Disc Degeneration and Repair
3.2 Emerging Tissue Engineering and Regenerative Medicine Technologies for Orthopaedic Applications and Markets
	3.2.1 Bone Repair and Replacement
	3.2.2 Cartilage Repair and Replacement
		3.2.2.1 Cartilage Autograft Implantation System
		3.2.2.2 Other Emerging Cartilage Repair and Replacement Technologies
	3.2.3 Meniscus Repair and Replacement
	3.2.4 Tendon and Ligament Repair and Replacement
	3.2.5 Spinal Disc Repair and Replacement
	3.2.6 Market Size, Market Potential and Forecast for Orthopaedic Applications
3.3 Market Drivers and Limiters
3.4 Leading Companies in Orthopaedic Tissue Engineering

Exhibit 3.1:  Patient Visits to Orthopaedic Surgeons, U.S., 1999-2005
Exhibit 3.2:  Total Orthopaedic Surgery Procedures and Breakdown by Major Procedure, U.S., 2006
Exhibit 3.3:  Worldwide Orthopaedic Surgery Procedures and Products Market, 2007
Exhibit 3.4:  Ligament and Tendon Repair Procedures and Breakdown by Procedure, U.S. 2006
Exhibit 3.5:  Tissue Engineering Cartilage Repair and Replacement Technologies
Exhibit 3.6:  Worldwide Orthobiologic Products Market, 2007
Exhibit 3.7:  2007 Sales and Market Share for Leading Suppliers in the Orthopaedic Tissue Engineering and Regenerative Medicine Market
Exhibit 3.8:  2008 Sales and Market Share for Leading Suppliers in the Orthopaedic Tissue Engineering and Regenerative Medicine Market
Exhibit 3.9:  Worldwide Market for Tissue-Engineered Orthopaedic Products, 2007-2013
Exhibit 3.10: Worldwide Target Market for Orthopaedic Applications by Segment
Exhibit 3.11: Worldwide Target Procedures for Orthopaedic Applications by Region and Segment, 2007
Exhibit 3.12: Worldwide Potential Markets for Orthopaedic Applications by Region and Segment, 2007
Exhibit 3.13: Leading Companies in Orthopaedic Tissue Engineering

CHAPTER 4: APPLICATIONS AND MARKETS IN NEUROLOGY

4.1 Neurological Disease Prevalence and Incidence
4.2 Tissue Engineering and Regenerative Medicine Technologies for Neurological Applications and Market Potential
	4.2.1 Tissue Engineering and Regenerative Medicine for Spinal Cord Injury and Amytrophic Lateral Sclerosis
	4.2.2 Cell Implants for Parkinson's Disease
	4.2.3 Cell Transplants for Epilepsy Treatment
	4.2.4 Stem Cell Therapy for Multiple Sclerosis
	4.2.5 Cell Therapy for Peripheral Nerve Injury
	4.2.6 Tissue Engineering Therapies for Stroke
	4.2.7 Tissue Engineering Therapies for Alzheimer's Disease
	4.2.8 Tissue Engineering and Cell Transplant Therapies for Central Nervous System Disorders
4.3 Market Forecast for Neurological Applications
4.4 Market Drivers and Limiters
4.5 Leading Companies in Neurological Tissue Engineering

Exhibit 4.1: Worldwide Prevalence of Major Neurological Diseases by Region, 2005
Exhibit 4.2: Worldwide Trends in Prevalence for Major Neurological Disorders, 2005-2030
Exhibit 4.3: Annual Incidence for Major Neurological Disorders
Exhibit 4.4: Tissue Engineering Technologies for Treatment of Neurological Disorders
Exhibit 4.5: Stroke Statistics for the U.S., 2005
Exhibit 4.6: Existing Therapies for Alzheimer's Disease
Exhibit 4.7: Worldwide Target Market for Neurological Applications by Disease Segment
Exhibit 4.8: Leading Companies in Neurological Tissue Engineering and Regenerative Medicine

CHAPTER 5: APPLICATIONS AND MARKETS IN UROLOGY

5.1 Urological Disease Incidence and Prevalence
5.2 Tissue Engineering and Regenerative Medicine Technologies for Urological Applications and Market Potential
	5.2.1 Treatment of Urinary Incontinence and Bladder Repair
	5.2.2 Ureter Repair and Replacement
	5.2.3 Urethral Repair
	5.2.4 Penile Reconstruction
	5.2.5 Tissue Engineering for Treatment of Vesicoureteral Reflux
	5.2.6 Gene Therapy for Urological Dysfunction
5.3 Market Forecast for Urological Applications
5.4 Market Drivers and Limiters
5.5 Leading Companies in Urological Tissue Engineering

Exhibit 5.1: Worldwide Incidence/Prevalence of Major Urological Diseases and Procedures by Region, 2007
Exhibit 5.2: Prevalence of Urinary Stress Incontinence by Degree of Severity and Region, 2007
Exhibit 5.3: Products for Treatment of Urinary Incontinence
Exhibit 5.4: Penile Prosthesis Products
Exhibit 5.5: Worldwide Urological Implant Device Market, 2007-2013
Exhibit 5.6: Worldwide Urological Tissue-Engineered Device Market versus Total Market, 2007-2013
Exhibit 5.7: Supplier Sales and Market Share in the Urological Implant Products Market, 2007
Exhibit 5.8: Supplier Sales and Market Share in the Urological Implant Products Market, 2008
Exhibit 5.9: Worldwide Target Market for Urological Applications by Disease Segment

CHAPTER 6: ORGAN REGENERATION TECHNOLOGIES AND MARKETS

6.1 Existing Products for Organ Supplementation
6.2 Organ Transplantation
6.3 Technologies for Organ Regeneration
	6.3.1 Liver Regeneration
	6.3.2 Pancreas and Islet Cell Regeneration
	6.3.3 Kidney and Renal Tubule Regeneration
	6.3.4 Small Intestine Regeneration
	6.3.5 Bone Marrow Regeneration
	6.3.6 Heart Regeneration
6.4 Emerging Markets for Organ Regeneration
6.5 Organ Regeneration Market Drivers and Limiters
6.6 Leading Companies in Organ Regeneration


Exhibit 6.1: Worldwide Trends in Dialysis Patients by Region
Exhibit 6.2: Ventricular Assist Devices and Artificial Hearts for Heart Supplementation and Replacement
Exhibit 6.3: Worldwide Sales in the Heart Assist and Replacement Device Market
Exhibit 6.4: U.S. Organ Transplant Procedures and Transplant Recipient Waiting List, 2000-2007
Exhibit 6.5: Organ Transplant Procedures and Registrations on Recipient Waiting List in Eurotransplant Countries, 2003-2007
Exhibit 6.6: U.S. Hospital Discharges with a Diagnosis of Liver Disease, 1995 and 2005
Exhibit 6.7: Worldwide Prevalence of Diabetes by Region, 2000 and 2030
Exhibit 6.8: Worldwide Target Market for Organ Regeneration Products
Exhibit 6.9: Leading Companies in Organ Regeneration

CHAPTER 7: TISSUE ENGINEERING & REGENERATIVE MEDICINE FOR WOUND MANAGEMENT, SKIN REPAIR & SKIN ULCER TREATMENT

7.1 Wound and Skin Disease Incidence and Prevalence
7.2 Tissue Engineering and Cell Transplantation Technologies for Wound Management, Skin Repair and Skin Ulcer Treatment and Market Potential
	7.2.1 Wound Management
	7.2.2 Burn Treatment
	7.2.3 Skin Ulcer Treatment
	7.2.4 Hernia and Soft Tissue Repair
7.3 Market Analysis Forecast for Tissue Engineering and Regenerative Medicine Products for Wound Management, Skin Repair and Skin Ulcer 
     Treatment
7.4 Market Drivers and Limiters
7.5 Competitor Analysis for Tissue Engineering and Regenerative Medicine Market for Wound Management, Skin Repair and Ulcer Treatment

Exhibit 7.1: Wound and Skin Disease Incidence and Prevalence, 2007
Exhibit 7.2: Plastic and Reconstructive Surgery Procedures in the U.S., 2007
Exhibit 7.3: Tissue Engineering and Regenerative Medicine Products for Wound Management, Skin Repair, and Skin Ulcer Therapy
Exhibit 7.4: Applications of Tissue-Engineered Wound and Skin Repair Products
Exhibit 7.5: Worldwide Market for Tissue-Engineered Wound Management Products, 2007-2013
Exhibit 7.6: Tissue-Engineered Wound Management Product Supplier Sales and Market Share by Region, 2007
Exhibit 7.7: Tissue-Engineered Wound Management Product Supplier Sales and Market Share by Region, 2008

CHAPTER 8: COMPETITOR ASSESSMENT

8.1 Overview of Tissue Engineering and Regenerative Medicine Companies
8.2 Acquisitions, Mergers and Partnerships to Improve Competitive Position
8.3 Technology Portfolio Analysis for Leading Tissue Engineering and Regenerative Medicine Companies

Exhibit 8.1: Overview of Leading Competitors in the Tissue Engineering and Regenerative Medicine Market
Exhibit 8.2: Recent Acquisitions, Mergers and Partnerships in the Tissue Engineering and Regenerative Medicine Market
Exhibit 8.3: Technology Portfolio Analysis for Key Companies in the Tissue Engineering and Regenerative Medicine Market

CHAPTER 9: SELECT COMPANY PROFILES (full report includes coverage of 227 companies)

9.1 Aastrom Biosciences
9.2 Advanced BioHealing
9.3 Advanced Cell Technology
9.4 Aldagen
9.5 Arteriocyte
9.6 Athersys
9.7 Biofisica
9.8 Bioheart
9.9 BioMimetic Therapeutics
9.10 Cardium Therapeutics
9.11 CeraPedics
9.12 Cook Biotech
9.13 CrossCart
9.14 CryoLife
9.15 Cytograft Tissue Engineering
9.16 Cytori Therapeutics
9.17 Gamida Cell Ltd.
9.18 GeneGrafts
9.19 GenVec
9.20 Genzyme
9.21 Geron
9.22 Integra LifeSciences
9.23 International Stem Cell
9.24 Isolagen
9.25 LifeCell/Kinetic Concepts
9.26 Mesoblast
9.27 MicroIslet
9.28 Neuralstem
9.29 Novocell
9.30 Organogenesis
9.31 Orthopeutics
9.32 Osiris Therapeutics
9.33 Pluristem Therapeutics
9.34 ReGen Biologics
9.35 ReNeuron
9.36 Scil Technology
9.37 StemCells Inc.
9.38 StemCor Systems
9.39 Tengion
9.40 Tepha

Companies Covered

3H Biomedical
Aastrom Biosciences
AbioMed
ACell
Advanced BioHealing
Advanced Cell Technology
Aesculap/B. Braun
Agera Laboratories
Aldagen
American Medical Systems
Amgen
Amorcyte
AMS Medical Solutions
Angel Biotechnology
AnGes MG
Angioblast Systems
Anthrogenesis
Applikon Biotechnology
Arteriocyte
Arthrokinetics
Athersys
Atrium Medical
BabyTooth Technologies
Bard Peripheral Vascular
Baxter Healthcare
Bayer Schering Pharma
Berkeley Advanced Biomaterials
Berlin Heart
BioCancell Therapeutics
BioEden
Biofisica
Biogen
Bioheart
BioMimetic Therapeutics
BioSyntech
Bioteck
BioTransplant
Boston Scientific
Bristol Myerers Squibb
Carbon Medical Technologies
Capricor
Cardio3 BioSciences
Cardium Therapeutics
CBR Systems
Cellerant Therapeutics
Cellerix
Cell Genesys
Cells for Life
Celltran
Cellulogix International
Celprogen
Cerapedics
CJ CheilDejang
CoAxia
Co.don
Coloplast
Cook Group/Cook Biotech
CorCell/Cord Blood America
Cordis
CORD:USE
CordPartners (CorCell)
Concentric Medical
Cousin Biotech
Covidien
C.R. Bard
CrossCart
Cryobanks International
CryoCell International
CryoCord
CryoLife
Cryo-Save Group
Curative Biosciences
Curis
Cyberkinetics Neurotechnology Systems
Cyberonics
Cytograft Tissue Engineering
Cytori Therapeutics
DePuy Orthopaedics
DomaniCell
Edwards Lifesciences
Elan Pharmaceuticals
Eli Lilly
Eisai Pharmaceuticals
ES Cell International
Ethicon
Fenwal
Fidia Farmaceuticis
Forest Pharmaceuticals
Forticell Bioscience
Fresenius Medical Care
Future Health Technologies
Gambro
Gamida Cell
GeneGrafts
Geistlich Pharma
GenVec
Genzyme
Geron Corporation
GlaxoSmithKline
Glen Mills
Glycosan BioSystems
Harvet Technologies
Healthcord Cryogenics
Haemonetics
Healthpoint
HemaCare
Histogenics
Hospira
Humacyte
ICOS Therapeutics
Insception Biosciences
Integra LifeSciences
International Stem Cell
Isolagen
ISTO Technologies
ITxM Cord Blood Services
Jarvik Heart
JCR Pharmaceuticals
Jecoli
J&J Gynecare
J&J Mitek
J&J Regenerative
J.P. McCarthy Cord Stem Cell Bank
Kensey Nash
Kinetic Concepts
LifebankUSA
LifeCell
LifeCord
LifeLine Cord Blood Bank
Macropore Biosurgery
Matricel
MAZE Labs
Medical Device Alliance/Arthrocare
Medisorb Technologies
Medtronic
Mesoblast
MicroIslet
MicroMed Cardiovascular
Mirus Bio
Miltenyi Biotech
MultiCell Technologies
MultiGene Vascular Systems
Musculoskeletal Transplant Foundation
Mylan Bertek Pharmaceuticals
Neomedic
New Brunswick Scientific
Neuralstem
NeuroMetrix
Neuronyx
Neurotech
Newborn Blood Banking
NMT Medical
Novartis
NovaThera/MedCell Bioscience
Novocell
NuVasive
Olympus
OrbusNeich
Organogenesis
Ormed
Orthofix
Orthogen
Ortho-McNeil
Orthopeutics
Osiris Therapeutics
Osteopore International
Osteotech
Pegasus Biologics
Pervasis Therapeutics
Pfizer
Pioneer Surgical
Plureon
Pluristem Therapeutics
Progenitor Cell Therapy
Promedon
Protein Polymer Technologies
Q Therapeutics
ReGen Biologics
Regenerative Sciences
ReGenLab
RenaMedical Biologics
ReNeuron Group
SaluMedica
Saneron CCEL Therapeutics
Sanofi Aventis
Sartorius
Sciele Pharma
Scil Technology
SecuraCell
Sewon Cellontech
Smith & Nephew
Stem Cell Innovations
StemCells
StemCell Technologies
StemCell Therapy International
StemCor Systems
StemCyte International
Stemedica Cell Technologies
Stem Sciences Cord Blood Bank
StemTech International
St. Jude Medical
Stryker
SynCardia Systems
Symetis
Tengion
Tepha
TETEC Tissue Engineering Technologies
Teva Pharmaceutical
Theradigm
Therics
Thoratec
TiGenix
Tissue Repair Company
Titan Pharmaceuticals
Uromedica
Uroplasty
ViaCord
ViCal
W.L. Gore & Associates
World Heart
Wyeth
XMEDICA
Zellwerk
Zen-bio
Zimmer