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Q3 Emerging Medical Technologies Report

114 Pages | 86 Exhibits |
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Overview

This report includes details on 86 companies that: presented at LSI's Q3 2011 Emerging Medical Technologies Spotlight meeting or have been identified by LSI's in-house research team in Q3 2011.

All companies include technology, market(s), key executive, and contact information.

Two- to three-page executive summaries are provided on some of the companies. Executive summaries typically include:

• Company Contact Information
• Company Overview (structure, size, year founded, etc.)
• Competitive Landscape
• Technological Advantage
• Stage of Development
• Target Markets
• Financial Summary and Sales Forecasts
• Financing & Partnering Needs
• IP Position & Status
• Management Team
• Exit Strategy
• More

Coverage includes innovations in a broad spectrum of medical technology areas including:
- 6 Aesthetics/Dermatology Companies
- 16 Biomaterials Companies
- 20 Biotechnology/Cell Therapy Companies
- 19 Cardiovascular Companies
- 2 Dental Companies
- 19 Diagnostics Companies
- 15 Drug Delivery Companies
- 10 Endocrine Companies
- 10 Gastroenterology Companies
- 11 Gynecology/Women's Health Companies
- 11 Imaging Companies
- 13 Neurology Companies
- 17 Oncology Companies
- 5 Ophthalmology Companies
- 7 Orthopedics Companies
- 6 Pain Management Companies
- 16 Patient Monitoring/Management Companies
- 9 Respiratory Companies
- 3 Spine Companies
- 15 Surgery Companies
- 5 Urology Companies
- 13 Vascular Companies
- 4 Wound Management Companies

This report is included in LSI's Emerging Medical Technologies® Database.

Table of Contents

BRIEF TECHNOLOGY DESCRIPTIONS FOR COMPANIES COVERED

• 1-A spray drying technology to enable the storage of plasma in diverse environments by methods that are far simpler/less costly than those used currently and 2-A product to enable platelets to be stored in refrigerators rather than at room temperature to: (i) improve safety, (ii) extend shelf life, and (iii) significantly reduce costs
• A biopharmaceutical company with an extensive library of structurally diverse bioactive peptides with broad applications in the health, beauty, and pharmaceutical industries
• A disposable skin patch that provides diabetics with a painless, BLOODLESS, easy-to-use, and rapid method for monitoring glucose levels
• A family of single-use devices that provide quantitative pressure measurements, while alleviating doubt and uncertainty during common medical procedures such as central line insertions, spinal taps, and epidurals
• A genomics diagnostic tool company, with a transformative technology that integrates sample preparation and sequencing on a chip, delivering actionable data in the doctor's office; supported by a $30 million large grant project with access to 15 million samples associated with cradle to grave electronic medical records established a decade ago
• A hand-held device with a touch-screen interface that identifies a patient's preferred language and then collects his/her information, medical history, symptoms, and complaints, which are then summarized into the caregiver's language and can be accessed on the device/through a facility's electronic health records (EHR) system
• A mechanical thrombectomy kit that will help restore blood flow and reduce hemorrhagic complications associated with acute ischemic stroke therapy
• A non-invasive hand-held system for accurately measuring circulating blood volume in real-time, to quickly identify and treat shock
• A non-invasive, safe cardiac diagnostic system that in a 10-minute test reliably detects existence or absence of ischemia and monitors treatment efficacy
• A take-home conception aid system that is designed to address the growing unmet need of delayed/unsuccessful natural fertility that historically has had similar results to intrauterine insemination (IUI), yet can now be done in the privacy of the home
• A unique lipid-soluble anti-oxidant heavy metal chelator that is safe and effective, for which the company is pursuing orphan drug approval
• AdaptDx - A novel diagnostic instrument that can detect and track age-related macular degeneration (AMD) from its beginning stages, allowing for early intervention
• Advanced medical technology that combines CO2 laser capabilities with autologous stem cells to significantly improve cardiac output in patients with heart disease or heart failure
• Aerosol-based inhaled insulin delivery device
• An accurate, low-cost home healthcare device for use by patients to self-measure Intraocular Pressure (IOP)
• An interactive, computer-assisted system utilizing image-guided robotics to enhance the quality of hair follicle harvesting during hair restoration surgery
• Biologically compatible polymers that provide non-surgical regenerative therapies for treating chronic and acute episodes of pain
• Bone anchorage technology for use in spine, trauma, and general orthopedics
• Cartilage repair using cell therapy - true, 100% hyaline cartilage tissue, in a single procedure, using an off-the-shelf product
• Compounds for oncology indications, including: 1-the prevention of A) chemotherapy-induced nausea and vomiting (CINV), B) post-operative nausea and vomiting (PONV), and C) chronic cough and 2-treatment for patients with non-small cell lung cancer (NSCLC) whose tumors express an Anaplastic Lymphoma Kinase (ALK) fusion protein
• Device for the intraocular delivery of photoactive nanoparticles for the treatment of retinitis pigmentosa, macular degeneration, and diabetic retinopathy
• Device used to safely deliver epidural anesthesia during childbirth and other procedures
• Diagnostic tests that leverage the ability to extract clinically relevant information from maternal blood, including a non-invasive prenatal test to diagnose specific genetic and other inherited disorders
• Drugs to treat breast and other cancers by targeting cancer stem cells
• Easy, safe, and convenient injection of drugs and vaccines in a solid dosage form using the Glide SDI(R) (Solid Dose Injector)
• Electrophysiological mapping device for the treatment of complex cardiac arrhythmias
• Energy-based thermal surgery device that provides better soft tissue cutting and coagulation
• Fine-needle aspiration system for use in interventional endoscopic procedures
• Flexible patch applied over the neck that uses light wavelengths to produce and control the production of nitric oxide (NO) in vascular tissue leading to the brain, for the treatment of Alzheimer's and other neurological disorders
• Genetic test for expectant mothers that detects spina bifida
• Hand-held device that sublingually monitors changes in carbon dioxide (CO2) levels for the prevention of septic shock
• Hand-held, disposable device that transdermally removes spider and reticular veins without a sclerotherapy agent
• Hand-held, non-contact vein illumination device for imaging veins just below the surface of the skin
• Immediate detection and identification of bacteria in bodily fluids through optical spectroscopy with low quantities of material without bacteria culturing
• Immunomagnetic cell capture system which isolates and removes pathogens directly from the blood in under 30 minutes
• Implantable neurostimulation device for the treatment of obstructive sleep apnea (OSA)
• Implantable, wireless, intracranial pressure monitor for use in patients with tumors, prior strokes, and traumatic brain injuries (TBI)
• ImplantLock, a device that enables a safe alternative to vertical bone augmentation or sinus lifting as well as immediate functional loading even after tooth extraction
• Innovative single-use surgical retractors designed to manage all MIS exposure needs in gynecological, digestive, visceral, and vascular surgery
• Integrated molecular diagnostic system that is easy to use and requires little or no training
• Liver dialysis system that removes protein-bound toxins plus water-soluble toxins from blood and is more effective and cost-efficient than currently available therapies
• Low-cost mobile device and software that adapts smartphones into ECG machines
• Micro-needle skin patch for delivery of the influenza vaccine
• Miniature infrared thermal imaging cameras combined with a spectroscopic infrared real-time in vivo analysis device for the early detection/accurate identification of internal lesions and tumors, as an add-on to existing endoscopes
• Miniaturized, continuously adaptable, left ventricular assist device (LVAD) for the treatment of heart failure
• Minimally invasive memory polymer devices for use in peripheral vascular, non-vascular, and neurovascular applications
• Minimally invasive protostatic reshaping device for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia (BPH)
• Molecular testing that analyzes gene expression in airway epithelial cells to detect early signs of lung cancer
• Needle-free silicone patch for vaccine delivery
• Next-generation PCR system that can provide absolute quantification of nucleic acid molecules, at higher resolution and lower target levels than the current standard, thereby identifying diseases earlier in progression
• Non-invasive device to alleviate the symptoms of subjective tinnitus that synchronously presents sound using headphones and tactile representations to an intra-oral array on the tongue
• Non-invasive disposable device to automatically deliver a new therapy called *Remote Ischemic Preconditioning*, an adjunct to traditional treatments for heart attack and stroke that mitigates ischemia-reperfusion injury and has been clinically shown to reduce infarct size by 50%, without side effects
• Non-invasive neuromodulation device that exposes the brain to an oscillating magnetic field, for the treatment of psychiatric and neurological disorders such as major depressive disorder and bipolar depression
• Non-invasive nitric oxide gas (gNO) technology and iontophoresis drug delivery for treating diseases of the skin and nails
• Non-systemically absorbed compounds for the treatment of diabetes and obesity, as an alternative to gastric bypass surgery
• Novel and clinically-validated percutaneous approach for the treatment of functional mitral regurgitation in the heart failure population
• Ozone injection system for multiple spinal applications, including herniated disc, to eliminate the need for multiple steroid injections and/or a surgical discectomy
• P.L.E.A.S.E.(R) (Precise Laser Epidermal System) - a novel transdermal delivery device for high molecular weight drugs, that can be used by medical personnel or the patient
• Pancreatic islet cell transplantation as a potential cure for Type I diabetes
• Patient monitoring system providing real-time continuous information via four physiological parameters - sensed at the tissue level, reflecting the patient's systemic metabolic state
• Portable, self-contained system for the precise minimally invasive removal of diseased tissue, to restore natural tendon and soft tissue function in the elbow, knee, ankle, foot, and shoulder
• Prefilled, easy-to-carry epinephrine auto-injection device for people with severe allergies
• Products for surgical RF ablation, valve replacement or repair, and coronary artery bypass (CABG) grafting
• Radiofrequency balloon catheter technology
• Real-time orthopedic surgery imaging system that will save valuable time for surgeons and hospitals, while improving surgery accuracy and patient safety
• Real-time vital signs monitoring with data collected from earbuds and streamed wirelessly to mobile devices or the web for viewing
• Regenerative stem cell therapy to treat heart failure (HF), acute myocardial infarction (MI), angina, peripheral artery disease (PAD), and hard-to-heal wounds including burns, diabetic foot ulcers, venous stasis ulcers, and pressure ulcers
• Self-expanding, fully removable, temporary inferior vena cava (IVC) filter used in conjunction with the placement of a central line for the prevention of pulmonary embolism
• Small molecule plasma kallikrein inhibitors for the treatment of diabetic macular edema (DME)
• Small, discrete, and disposable device to reduce food intake
• Software for efficiently coordinating the delivery of patient care outside of hospitals; it optimizes home care operations and can turn a medical practice into an ACO
• Subcutaneously implanted drug delivery device for slow and consistent release of therapeutic agents over a period of weeks or months, as an alternative to current treatments with a long regimen of injections and/or clinical visits
• Superior nasal drug delivery that can increase therapeutic drug concentrations in the brain and lower drug concentrations in the blood
• Synthetic 3D extracellular matrices to support tissue growth for use in a wide range of regenerative medicine
• System that is capable of simultaneous quantitative and independent determination of up to 100 biomarkers in individual cells, not possible with existing technologies, for early disease diagnosis and monitoring of treatment efficacy
• Technologies that: 1-Temporarily plug body passageways with a thermo-transitioning gel that is delivered as a cold liquid, solidifies at body temperature, and is later flushed away and 2-Keep body passageways open with gentle passively dilating devices, as well with more rigid construction of an open design, to prevent eventual long-term blockage
• Temporary implantable ventricular assist device (VAD) that wraps around the heart and squeezes it to help pump blood
• The first miniature and highly accurate guide for brain surgery that is fully MRI-compatible and gives the possibility to perform simultaneous bilateral procedures, in addition to being easy-to-use and cost-effective
• The first non-invasive, prep-free imaging test for colon cancer
• The next major step in the treatment of early breast cancer: replacing lumpectomy with a percutaneous, minimally invasive outpatient procedure under local anesthesia that not only eradicates the cancer, but is not disfiguring and leaves no scar
• The only device-based therapy, offering low-cost and non-invasive treatment for a wide range of antenatal conditions; thereby promising to prevent preterm birth
• The technology, based on growth factor extract from reindeer bones, improves bone formation in bone healing problems
• Thermal pulsation system for effective, in-office treatment of evaporative dry eye
• Unit-dose, prefilled, room-temperature stable vaccine reconstitution and delivery device
• Wireless, non-invasive, and portable brainwave recording device for convenient at-home sleep monitoring and analysis to: 1-offer insight into the diagnosis and treatment of conditions such as Alzheimer's, autism, cancer, epilepsy, depression, and schizophrenia and 2-reveal how drugs affect the brain
• X-ray light valve device for use in conjunction with mammography screening and future imaging modalities