Global Opportunities in Cerebral Embolization Markets

Published January 2020 | 102 Pages | 41 Exhibits | Forecasts Through 2023

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Overview

Although the number of cerebral embolization procedures performed globally is fairly limited relative to many other interventions, the associated product sales are impressive:  estimated at $1.75 billion globally in 2018, representing roughly $11,300 per procedure.  These high outlays—which include not only the specialized coils, liquid embolics, flow diverters and stent-assisted coil devices but also the microcatheters, microguidewires, access devices, micro-occluding balloons and other devices employed ancillary to them—reflect two major factors.  The first is the specialized “micro” nature of neuro-interventional products, which creates design and quality control challenges for manufacturers.  The second is the limited number of procedures, which precludes the production economies of scale necessary to attract new suppliers and support competitive pricing.  In essence, neurointerventional products carry premium prices because they are premium products.  Even the fairly recent influx of new flow diversion products did not create downward pricing pressure in that segment as expected; rather, pricing increased slightly.  Thus, we have not incorporated an expectation of downward pricing pressure into our forecast for cerebral embolization products as procedure volumes are not expected to reach a critical mass.  Nevertheless, product sales are projected to increase at an 8.0% real annual rate through 2023 to $2.58 billion, representing nearly $12,000 per procedure.  

Competitors covered in this analysis include:

  • Acandis
  • BALT
  • J&J Cerenovus
  • Medtronic
  • MicroPort Medical
  • Penumbra
  • Phenox
  • Rapidmedical
  • Stryker
  • Terumo MicroVention
  • Others

 

Table of Contents

Executive Summary

Cerebral Embolization Procedures

Embolization Products Market

Supplier Shares

 

Summary Exhibit 1: Global Trend in Subarachnoid Hemmorrhage (SAH), Intact Cerebral Aneurysms (CAs), Arteriovenous Malformations (AVMs) and Associated Embolization Procedures, 2018-2023

Summary Exhibit 2: Trends in SAH/Aneurysm Embolizations and AVM Embolizations, by Major Geography, 2018-2023

Summary Exhibit 3: Global Trend in Cerebral Embolization Products Market, by Major Category, 2018-2023

Summary Exhibit 4: Global Sales of Cerebral Embolization Products, by Major Geography, 2018-2023

Summary Exhibit 5: Global Cerebral Embolization Products, Supplier Shares, 2018

 

1. Etiology & Epidemiology of Acute Stroke

1.1 Overview of the Brain

1.1.1 Cerebral Arterial Blood Supply

1.2 Etiology of Stroke

1.2.1 Ischemic Stroke

1.2.1.1 Causative Mechanisms

1.2.1.2 Symptoms

1.2.1.3 Risk Factors

1.2.1.4 Diagnosis

1.2.1.5 Treatment

1.2.1.6 Incidence

1.2.2 Hemorrhagic Stroke

1.2.2.1 Intracerebral Hemorrhage

1.2.2.1.1 Symptoms

1.2.2.1.2 Diagnosis and Treatment

1.2.2.2 Subarachnoid Hemorrhage

1.2.2.2.1 Causes and Risk Factors

1.2.2.2.2 Symptoms

1.2.2.2.3 Diagnosis

1.2.2.2.4 Treatment

1.2.2.3 Incidence

 

Exhibit 1-1: Overview of the Brain

Exhibit 1-2: Arterial Blood Supply to Brain

Exhibit 1-3: Comparison of Ischemic and Hemorrhagic Stroke

Exhibit 1-4: Global Incidence of Ischemic and Hemorrhagic Stroke, 2018-2023

Exhibit 1-5: Incidence of Ischemic and Hemorrhagic Stroke, United States, 2018-2023

Exhibit 1-6: Incidence of Ischemic and Hemorrhagic Stroke, Major Europe, 2018-2023

Exhibit 1-7: Incidence of Ischemic and Hemorrhagic Stroke, Major Asia-Pacific, 2018-2023

Exhibit 1-8: Incidence of Ischemic and Hemorrhagic Stroke,  Rest-of-World, 2018-2023

Exhibit 1-9: Comparison of Intracerebral and Subarachnoid Hemorrhage

 

2. Embolization Approaches to Stroke Management

2.1 Hemorrhagic Stroke Targeted Pathologies

2.1.1 Intracranial Aneurysms

2.1.2 Arteriovenous Malformations (AVMs)

2.2 Management Options

2.2.1 Surgical Repair

2.2.2 Endovascular Embolization

2.2.2.1 Microcoil Systems

2.2.2.2 Liquid Embolic Systems

2.2.2.3 Coil-Containing Stent Systems

2.2.2.4 PVA Particles and Beads

2.2.2.5 Neurovascular Occlusion Balloons

2.2.2.6 Occlusion Meshes

2.2.2.7 Flow Diverting Embolization Systems

2.3 Procedures

 

Exhibit 2-1: Comparison of Endovascular Approaches & Products for Stroke Management

Exhibit 2-2: Cerebral Aneurysm and Arteriovenous Malformation

Exhibit 2-3: Comparison of Endovascular Approaches & Products for Stroke Management

Exhibit 2-4: Surgical Aneurysm Clipping

Exhibit 2-5: Comparison of Cerebral Embolic Agents and Approaches

Exhibit 2-6: Selected Microcoil Products, 2019

Exhibit 2-7: Selected Coil-Containing Stent Systems, 2019

Exhibit 2-7: Selected Coil-Containing Stent Systems, 2019 (Continued)

Exhibit 2-8: Selected Neurovascular Occluding Balloons, 2019

Exhibit 2-9: Selected Neurovascular Occluding Meshes, 2019

Exhibit 2-10: Results of Selected Clinical Trials of Flow Diversion Embolization Systems

Exhibit 2-11: Selected Flow Diversion Embolization SystemsCoil-Containing Stent Systems, 2019

Exhibit 2-12: Global Endovascular Embolizations for Cerebral Aneurysms, 2018-2023

Exhibit 2-13: United States Endovascular Embolizations for Cerebral Aneurysms, 2018-2023

Exhibit 2-14: Major Europe Endovascular Embolizations for Cerebral Aneurysms, 2018-2023

Exhibit 2-15: Major Asia-Pacific Endovascular Embolizations for Cerebral Aneurysms, 2018-2023

Exhibit 2-16: Rest-of-World Endovascular Embolizations for Cerebral Aneurysms, 2018-2023

 

3. Product Markets

3.1 Market by Major Segment

3.1.1 Aneurysm Embolics and Associated Devices

3.1.2 AVM Embolics and Associated Devices

3.1.3 Supplier Shares

3.2 Market by Major Geography

 

Exhibit 3-1: Global Sales of Cerebral Embolization Products, by Major Segment and Geography,  2018-2023

Exhibit 3-2: Global Sales of Aneurysm Embolization Products, by Major Type, 2018-2023

Exhibit 3-3: Global Cerebral Embolization Products, Supplier Shares, 2018

Exhibit 3-4: United States Cerebral Embolization Procedures and Products, by Major Type, 2018-2023

Exhibit 3-5: United States, Cerebral Embolization Products, Supplier Shares, 2018

Exhibit 3-6: Major Europe Cerebral Embolization Procedures and Products, by Major Type, 2018-2023

Exhibit 3-7: Major Europe, Cerebral Embolization Products, Supplier Shares, 2018

Exhibit 3-8: Major Asia Pacific Cerebral Embolization Procedures and Products, by Major Type, 2018-2023

Exhibit 3-9: Major Asia-Pacific, Cerebral Embolization Products, Supplier Shares, 2018

Exhibit 3-10: Rest-of-World Cerebral Embolization Procedures and Products, by Major Type, 2018-2023

Exhibit 3-11: Rest-of-World, Cerebral Embolization Products, Supplier Shares, 2018

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