February Emerging Medical Technologies Report

Published January 2014 | 49 Pages | 60 Exhibits |

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This report includes details on 60 emerging medical technology companies that have been identified by LSI's in-house research team in February 2014. Additionally, read LSI's "Innovator of the Month" Interview with:

- George Hermann, President & CEO, Focal Therapeutics

All companies include technology, market(s), key executive, and contact information.

Coverage includes innovations in a broad spectrum of medical technology areas including:
- Aesthetics/Dermatology Companies
- Biomaterials Companies
- Biotechnology/Cell Therapy Companies
- Cardiovascular Companies
- Dental Companies
- Diagnostics Companies
- Drug Delivery Companies
- Endocrine Companies
- Gastroenterology Companies
- Gynecology/Women's Health Companies
- Imaging Companies
- Neurology Companies
- Oncology Companies
- Ophthalmology Companies
- Orthopedics Companies
- Pain Management Companies
- Patient Management/Monitoring Companies
- Pharmaceutical Companies
- Respiratory Companies
- Spine Companies
- Surgery Companies
- Urology Companies
- Vascular Companies
- Wound Management Companies

This report may be purchased separately or is automatically provided to subscribers of LSI's Emerging Medical Technologies® Database.


Table of Contents


•1-Extended-release implant that replaces the need for glaucoma patients to use daily eye drops and 2-A platform that offers a unique ability to design monodisperse particles of large or small molecules in order to develop next-generation ocular therapies
•1-Hydrogel soft tissue marker that is fully absorbable and visible under several imaging modalities and 2-Absorbable hydrogel spacer that reduces radiation injury to the rectal wall in men undergoing prostate radiotherapy
•1-Single-use device that adds a visual dimension to locating a fistula and 2-A valve system that can selectively turn on/off the flow of blood to the arteriovenous (AV) graft during/after dialysis sessions
•1-System to reduce the amount of dye (contrast) injected during commonly performed heart procedures, thus protecting kidneys from damage known as contrast induced nephropathy (CIN) and 2-A percutaneous technology that allows physicians to deliver targeted doses of antibiotics to the lower limb in patients with diabetes suffering from advanced foot infections
•A device for treating postpartum hemorrhage, the number one cause of maternal death
•A molecular diagnostics test to predict the likely success of radiation therapy in cancer patients
•A simple surgical tool, similar to a suture applier, for transvaginal uterine artery ligation
•A three-dimensional surgical marker that dramatically improves visualization of the treatment area for radiation planning and therapy
•A user-friendly and resource-effective, self-screening method to detect HPV, chlamydia and gonorrhea, and reduce rates of cervical cancer
•Adenosine-based therapeutic skin patch for a variety of large market indications, including: arthritis, crohn's disease, psoriasis, diabetes, diabetic nephropathy, infectious diseases, glaucoma, asthma, atherosclerosis, cancer, and cardiovascular stress imaging
•Adenoviral-based technology platform for the rapid development of oral vaccines that can target any viral or bacterial protein antigen
•Alternative to continuous positive airway pressure (CPAP) therapy for the treatment of obstructive sleep apnea (OSA)
•Arterial closure device for the large arterial punctures encountered in transvascular procedures such as abdominal aortic aneurysm repair and heart valve replacements
•Bio-active ferrofluids that aid in the diagnosis of cancer and cardiovascular disease
•Blood test to stratify ischemic stroke patients by cause, leading to timely diagnosis and treatment, resulting in cost savings and improvement in patient outcomes
•Body suit for babies that is fitted with non-contact machine-washable sensors that allow parents to monitor the infant's respiration, skin temperature, body position, and activity level via Bluetooth low energy connected to a home's WiFi connection
•Coating made of a superelastic shape memory alloy (SMA) spacer fabric that expands in vivo to improve osseointegration with hip, knee, shoulder, elbow, and spine implants
•Convenient, accurate, blood- and pain-free glucose reading technology
•Disruptive DNA-sequencing technology based on a simple label-free proprietary technology, enabling fast, accurate, and low-cost genetic testing
•Drug that normalizes abhorrent activity in the hippocampus to treat/prevent Mild Cognitive Impairment (MCI), early Alzheimer's disease (AD), and other memory disorders
•Drugs for ovarian cancer and other advanced solid tumors
•Drugs targeting the Transglutaminase 2 (TG2) pathway to treat multiple disease indications, with an initial focus in celiac disease
•Electrosurgical devices for tissue dissection and skin contraction, with applications in general and cosmetic surgery
•Extremity orthopedic products to restore motion while relieving pain
•Family of balloon dilatation catheters that incorporate tiny lithotripsy electrodes designed to increase the compliance of rigid vascular and valvular lesions prior to low-pressure dilation, thereby limiting injury to healthy tissue and overcoming significant limitations of current revascularization technologies
•Fully bioresorbable scaffold, which is designed to afford the strength of metal stents to assist the artery during the remodeling process following an interventional procedure, without leaving behind a permanent implant with inherent clinical limitations
•Generic Class III medical devices with an emphasis on the musculoskeletal therapeutic areas of: rheumatology, physiatry, orthopedics, and sports medicine
•Handheld, portable solutions for wound care, orthopedic care and real-time data capture, analytics and reporting
•High-definition imaging for precision venous access
•Immunotherapies for the treatment of cancer, fibrosis, hypercholesterolemia/atherosclerosis, and inflammatory diseases
•Immunotherapy platforms to treat a variety of high-risk cancers: 1-Chimeric antigen receptors (CAR) technology that targets cell surface antigens that are expressed on cancer cells and 2-T cell receptors (TCR) technology that detects alterations in intracellular proteins present in tumor cells
•Implantable electrospun neurosurgical meshes and related tools/accessories
•Injectable tissue liquid marker used to improve accuracy in the radiation treatment of patients with cancer
•Laser technology that provides unprecedented precision and control for the removal of delicate tissues during microsurgical procedures
•Line of surgical instruments and equipment
•Medical device for the minimally invasive, transcatheter treatment of structural heart valve disease and mitral regurgitation in patient segments that cannot undergo standard cardiac surgery
•Miniature, non-invasive device that utilizes body-penetrating microwave radar technology to remotely monitor the optimal combination of chronic heart failure (CHF) patient clinical parameters (e.g. lung fluid level, heart rate, breath rate, posture)
•Minimally invasive intelligent monitoring device for the detection of sepsis in the intensive care unit (ICU)
•Next-generation implantable neurostimulation devices, with an initial focus on spinal cord stimulation
•Non-invasive clinically-proven breathing techniques that can be used by patients in the comfort of their homes to alleviate the symptoms of chronic pulmonary problems such as chronic obstructive pulmonary disease (COPD), asthma, and sleep apnea
•Non-invasive colon cancer screening solution that enables doctors and radiologists to use computed tomography (CT) images of a patient's abdomen and display a 3D model of a patient's colon to identify most polyps or other abnormalities
•Non-invasive, battery-operated, and self-administered migraine therapy device worn on the back of the head at the onset of, or during, a migraine to relieve pain
•Non-invasive, electromagnetic therapies to regenerate tissue and organs that have been damaged by age or disease
•Optical biomarker system that can provide earlier and more accurate detection of most cancers by detecting molecular changes in nuclear structure, which are not detectable by conventional pathology
•Pipeline of specialty generic drugs that have an embedded drug delivery technology to make the formulation very challenging/complex, in order to provide significant barriers to competition
•Portable dispenser and badge system for healthcare workers that allows point-of-care hand hygiene, along with real-time data to drive behavior change
•Precision microblade system for the minimally invasive treatment of cellulite in the office setting
•Products to dramatically reduce medical radiation exposure without changing user image quality or workflow
•Proprietary laboratory instrument that automates time-sensitive, labor-intensive steps in an in vitro fertilization (IVF) laboratory
•Small molecule cancer drugs for genetically-defined populations
•Small molecules for the treatment of antibiotic resistant bacterial infections
•Surgical lighting system to provide surgeons with a simple, high quality illumination source for deep cavity surgical procedures
•Surgical navigation system that provides real-time computer-assisted guidance during the dental implant process with more accuracy and at less cost than the current standard of care
•Technology for controlling patient temperature in order to more effectively implement mild therapeutic hypothermia, maintain operative normothermia, and treat fever
•Technology for the rapid cessation of bleeding (hemostasis) and control of fluid leakage (sealant) during surgery and trauma care
•Technology that integrates robotics and ultrasound imaging to enable real-time, markerless targeting for radiation therapy
•The first biologically guided radiation therapy system for treating solid tumors throughout the body
•Therapeutic use of local skin mechanical stimulation to increase blood flow and heal chronic wounds
•Wearable, clinical-grade vital signs monitoring technology to help people proactively understand their bodies and improve health, with applications ranging from cardiac disease and hypertension monitoring to stress
•Whole-body hyperthermia treatment for ovarian cancer


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