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Baxter International, Inc
Cardica, Inc
Chase Medical, Inc
CryoLife, Inc
Edwards Lifesciences Corporation
Endoscopic Technologies, Inc
Getinge AG
Guidant Corporation (Boston Scientific)
Intuitive Surgical, Inc
Johnson & Johnson
Medtronic, Inc
Pall Corporation
Sorin Group
Terumo Corporation
EXECUTIVE SUMMARY
Procedure Trends
Total Revascularization Products Market
Traditional Cardiopulmonary Bypass Products
Minimally Invasive Cardiac Surgery Technologies
Beating Heart Surgery Products
Anastomosis Devices
Minimally Invasive Vessel Harvesting
Other Surgical Coronary Revascularization Products
Transmyocardial Revascularization
Cardiopulmonary Bypass Surgical Sealants
Adjunctive Technologies
Product Suppliers
Summary Exhibit 1: Coronary Revascularization, Procedures by Type, 2004-2010
Summary Exhibit 2: Surgical Coronary Revascularization Products, Market Forecast, 2004-2010
Summary Exhibit 3: Cardiopulmonary Bypass Products, Market Forecast, 2004-2010
Summary Exhibit 4: Minimally Invasive Cardiac Surgery Technologies, Market Forecast, 2004-2010
Summary Exhibit 5: Other Surgical Coronary Revascularization Products, Market Forecast, 2004-2010
Summary Exhibit 6: Cardiopulmonary Bypass Surgical Sealants, Market Forecast, 2004-2010
Summary Exhibit 7: Adjunctive CABG Surgery Technologies, Market Forecast, 2004-2010
Summary Exhibit 8: Leading Suppliers of Surgical Coronary Revascularization Products, 2005
1.0 OVERVIEW OF CARDIOVASCULAR DISORDERS
1.1 Components and Function
1.1.1 Heart
1.1.2 Cardiac Cycle
1.1.3 Blood Vessels
1.2 Disorders of Heart and Circulation
1.2.1 Hypertension
1.2.2 Coronary Heart Disease
1.2.3 Congestive Heart Failure
1.2.4 Cardiac Arrhythmias
1.2.5 Stroke
1.2.6 Rheumatic Heart Disease
1.2.7 Acquired Valve Disorders
1.2.8 Congenital Heart Defects
1.3 Cardiovascular Disease Diagnosis
1.3.1 Non-Imaging Techniques
1.3.2 Imaging Techniques
1.3.2.1 Radiographic Imaging
1.3.2.2 Echocardiography
1.3.2.3 Radionuclide Scanning
1.3.2.4 Magnetic Resonance Imaging
1.3.2.5 Coronary Angiography
1.3.2.6 Intravascular Ultrasound
1.3.2.7 Intracoronary Angioscopy
1.3.3 Emerging Diagnostic Modalities
1.3.3.1 In Vitro Cardiac Markers
1.3.3.2 Predictor Tests
1.3.3.3 Monoclonal Antibody-Based Imaging of Thrombosis
1.4 Treatment of Cardiovascular Disease
1.4.1 Medical Management
1.4.1.1 Traditional Medical Management
1.4.1.2 Lipid-Lowering Drugs
1.4.2 Surgical Intervention
1.4.2.1 Coronary Artery Bypass Surgery
1.4.2.2 Valve Surgery and Treatment of Congenital Heart Defects
1.4.2.3 Transmyocardial Revascularization
1.4.2.4 Surgical Management of Atrial Fibrillation
1.4.3 Transcatheter Therapies
1.4.3.1 Percutaneous Transluminal Coronary Angioplasty
1.4.3.2 Coronary Stenting
1.4.3.3 Laser Angioplasty
1.4.3.4 Atherectomy
1.4.3.5 Transcatheter Thrombectomy and Thrombolysis
1.4.3.6 Transcatheter Defect Repair
1.4.3.7 Percutaneous Transmyocardial Revascularization
1.4.3.8 Catheter Ablation of Arrhythmias
1.5 Determinants of CABG Caseload
1.5.1 Anatomy of Major Coronary Artery Systems
1.5.2 Overview of Left Main Disease
1.5.3 Characterization of Left Main Disease
1.5.3.1 Kyriakidis Study
1.5.3.2 Roeters van Lennep Study
1.5.4 NHDS Data on CABG Surgeries
1.5.5 Implications for CABG Surgery Caseload
1.5.6 Trials of Drug-Eluting Stents versus CABG Surgery
Exhibit 1-1: The Heart
Exhibit 1-2: Selected Data on Heart Disease, 2003
Exhibit 1-3: Estimated Costs of Cardiovascular Disease and Stroke, 2006
Exhibit 1-4: Overview of Major Heart and Circulatory Disorders
Exhibit 1-5: Comparison of Left and Right-Sided Heart Failure
Exhibit 1-6: Selected Types of Arrhythmia
Exhibit 1-7: Major Congenital Heart Defects
Exhibit 1-8: Techniques Used for Diagnosing Cardiovascular Disease
Exhibit 1-9: Principal Drugs Used in the Treatment of Cardiovascular Disease, 2006
Exhibit 1-10: Major Surgical Interventions for Cardiovascular Disease, 2006
Exhibit 1-11: Transcatheter Interventions for Cardiovascular Disease, 2006
Exhibit 1-13: Major Coronary Artery Systems
Exhibit 1-14: Comparison of Two Studies Characterizing Coronary Artery Disease
Exhibit 1-15: Kyriakidis: Vessels Involved in Coronary Artery Disease by Sex and Age Group
Exhibit 1-16: Kyriakidis: Significant Coronary Artery Disease by Lesion Site
Exhibit 1-17: Kyriakidis: Single-Vessel Coronary Artery Disease by Site, Sex and Age
Exhibit 1-18: Roeters van Lennep: Vessels Involved in Coronary Artery Disease by Sex
Exhibit 1-19: Roeters van Lennep: Significant Coronary Artery Disease by Lesion Site1-60
Exhibit 1-20: Roeters van Lennep: Single-Vessel Coronary Artery Disease by Lesion Site
Exhibit 1-21: Roeters van Lennep: Use of Revascularization by Vessel Involvement
Exhibit 1-22: Roeters van Lennep: Distribution of CABG Surgery Patients by Vessel Involvement
Exhibit 1-23: NHDS Data: Trend in Bypass Procedures by Type, 1987-2002
Exhibit 1-24: American College of Cardiology (ACC): Indications for CABG Surgery
Exhibit 1-25: CABG Surgery, Procedure Trend, 2004-2010
Exhibit 1-26: Selected Trials of PCI and DES versus CABG Surgery
2.0 CONVENTIONAL (STOPPED HEART) OPEN HEART SURGERY
2.1 Cardiopulmonary Bypass
2.1.1 Extracorporeal Circuit
2.1.2 Complications
2.1.3 Products
2.1.3.1 Blood Pumps
2.1.3.1.1 Roller Pumps
2.1.3.1.2 Centrifugal Pumps
2.1.3.2 Oxygenators
2.1.3.2.1 Design and Function
2.1.3.2.2 Add On Features
2.1.3.2.3 Products and Suppliers
2.1.3.3 Accessories
2.1.3.3.1 Blood Filters
2.1.3.3.2 Hemoconcentrators
2.1.3.3.3 Cannulae
2.1.4 Developments in Cardiopulmonary Bypass
2.1.4.1 Reduce Bypass Volume and Blood-Surface Contact
2.1.4.1.1 CardioVention
2.1.4.1.2 COBE/Sorin
2.1.4.1.3 Maquet/Getinge
2.1.4.1.4 Medtronic
2.1.4.1.5 Terumo Cardiovascular
2.1.4.2 Reduced Embolic Risk
2.1.4.2.1 Cardio Medical Solutions
2.1.4.2.2 Chase Medical
2.1.4.2.3 Edwards Lifesciences
2.1.4.2.4 Estech
2.1.4.2.5 Guidant/Boston Scientific
2.1.4.2.6 Novare Surgical Systems
2.1.5 New Coatings
2.2 Blood Recovery and Salvage
2.2.1 Cardiotomy Suction
2.2.2 Intraoperative Cell Washing and Autotransfusion
2.2.2.1 Protocol
2.2.2.2 Products and Technology
2.2.2.3 Comparative Performance
2.2.2.4 Product Trends
2.2.2.5 Procedures
2.3 Myocardial Protection
2.3.1 Cardioplegia Circuit
2.3.2 Access for Cardioplegia
2.3.3 Cold versus Warm Cardioplegia
2.3.4 Products and Technology
2.4 Procedure Forecasts
2.4.1 Coronary Artery Bypass Graft Surgery
2.4.2 Valve Procedures
2.4.3 Other Procedures
2.5 Product Markets and Supplier Shares
2.5.1 Blood Pumps
2.5.2 Cardiopulmonary Bypass Circuit Disposables
2.5.3 Autotransfusion Kits
2.5.4 Emerging Bypass Disposables
2.5.5 Supplier Shares
Exhibit 2-1: Product Requirements for Open Heart Surgery Supported by Cardiopulmonary Bypass
Exhibit 2-2: Schematic of Cardiopulmonary Bypass Circuit
Exhibit 2-3: Potential Complications Associated with Cardiopulmonary Bypass
Exhibit 2-4: Disposables Used During On-Pump Open Heart Surgery
Exhibit 2-5: Estimated Cost Components of Cardiopulmonary Bypass Circuit
Exhibit 2-6: Comparison of Roller and Centrifugal Pumps
Exhibit 2-7: Selected Heart-Lung Machines, 2006
Exhibit 2-8: Selected Centrifugal Pump Systems, 2006
Exhibit 2-9: Comparison of Soft-Shell and Hard-Shell Venous Reservoirs
Exhibit 2-10: Selected Membrane Oxygenators, 2006
Exhibit 2-11 Selected Filters Employed in Cardiopulmonary Bypass Circuit
Exhibit 2-12: Comparison of Major Approaches Used to Reduce Bypass Complications
Exhibit 2-13: Selected Technologies Reducing Bypass Volume
Exhibit 2-14: CardioVention CORx System
Exhibit 2-15: COBE Synergy Mini-Bypass Circuit
Exhibit 2-16: Maquet MECC System
Exhibit 2-17: Medtronic Portable Bypass System (PBS)
Exhibit 2-18: Medronic Resting Heart Platform
Exhibit 2-19: Terumo Cardiovascular Systems' Mini Perfusion Circuits
Exhibit 2-20: Selected Technologies Reducing Aortic Manipulation
Exhibit 2-21: Cardio Medical Solutions Baladi Inverter
Exhibit 2-22: Chase Medical Triumph Soft Occlusion Aortic Cannula
Exhibit 2-23: Edwards’ EMBOL-X Aortic Filter System
Exhibit 2-24: Estech Remote Access Perfusion Catheter
Exhibit 2-25: Blood Conservation Strategies for Cardiac Surgery
Exhibit 2-26: Selected Current and Emerging Cardiac Surgery Autotransfusion Systems, 2006
Exhibit 2-27: Haemonetics' CardioPAT System
Exhibit 2-28: Global Blood Resources' Hemobag
Exhibit 2-29: Major Indications for Open Heart Surgery
Exhibit 2-30: Trend in CABG Surgery by Approach, Procedure Forecasts, 2004-2010
Exhibit 2-32: Stopped Heart versus Beating Heart CABG Surgery, Procedure Forecast, 2004-2010
Exhibit 2-33: Total Cardiopulmonary Bypass Caseload, Procedure Forecast, 2004-2010
Exhibit 2-34: Cardiopulmonary Bypass Products, Market Forecast, 2004-2010
Exhibit 2-35: Traditional Heart-Lung Machines, Market Forecast, 2004-2010
Exhibit 2-36: Centrifugal Pump Consoles, Market Forecast, 2004-2010
Exhibit 2-37: Cardiopulmonary Bypass Disposables, Market Forecast, 2004-2010
Exhibit 2-38: Cardiac Surgery Autotransfusion Kits, Market Forecast, 2004-2010
Exhibit 2-39: Cardiac Surgery Autotransfusion Kits, Supplier Shares, 2005
Exhibit 2-40: Embolic Protection Devices, Market Forecast, 2004-2010
Exhibit 2-41: Cardiopulmonary Bypass Products, Supplier Shares, 2005
3.0 MINIMALLY INVASIVE CARDIAC SURGERY TECHNOLOGIES
3.1 Beating Heart Techniques
3.1.1 Clinical Indications
3.1.2 Procedure Forecast
3.2 Beating Heart Systems (Stabilizers and Positioners)
3.2.1 Products and Suppliers
3.2.1.1 Beating Heart Surgical Instruments (Vitalcor)
3.2.1.2 Boston Scientific
3.2.1.3 Chase Medical
3.2.1.4 CoroNéo
3.2.1.5 ESTECH
3.2.1.6 Ethicon (CardioVations)
3.2.1.7 MediVas OPCAB
3.2.1.8 Medtronic
3.2.1.9 Teleflex Medical
3.2.1.10 Tokyo Medical and Dental University
3.2.2 Market Analysis
3.3 Anastomosis Assist Devices
3.3.1 Products and Suppliers
3.3.1.1 Boston Scientific (Guidant)
3.3.1.2 Novare Surgical Systems
3.3.2 Market Analysis
3.4 Automated Anastomosis Devices
3.4.1 Design Criteria
3.4.2 Products and Suppliers
3.4.2.1 Cardica
3.4.2.1.1 PAS-Port Proximal Anastomosis System
3.4.2.1.2 C-Port Distal Anastomosis System
3.4.2.1.3 C-Port xA
3.4.2.1.4 C-Port Flex A
3.4.2.2 iiTech
3.4.2.3 Medtronic
3.4.2.3.1 U-Clip
3.4.2.3.2 Spyder
3.4.2.4 Rintek Systems
3.4.2.5 St. Jude Medical
3.4.3 Market Analysis
3.5 Intracoronary Shunts
3.5.1 Design
3.5.2 Application
3.5.3 Advantages and Limitations
3.5.4 Clinical Experience
3.5.5 Products and Suppliers
3.6 Intrasurgical Cardiac Assist
3.7 Minimally Invasive Vessel Harvesting
3.7.1 Graft Sources
3.7.1.1 Radial Artery Grafts
3.7.1.2 Gastroepiploic Artery Grafts
3.7.1.3 Internal Thoracic Artery Grafts
3.7.1.4 Artificial Coronary Grafts
3.7.2 Minimally Invasive Harvesting Techniques
3.7.2.1 Harvesting Technique
3.7.2.2 Advantages, Limitations and Guidelines
3.7.2.3 Products and Suppliers
3.7.2.3.1 Boston Scientific
3.7.2.3.2 Datascope
3.7.2.3.3 Ethicon (CardioVations)
3.7.2.3.4 Karl Storz Endoscopy
3.7.2.3.5 SurgRx
3.7.2.3.6 Teleflex Medical
3.7.2.3.7 Terumo Cardiovascular Systems
3.7.2.3.8 Tyco Healthcare
3.7.2.4 Market Analysis
Exhibit 3-1: Minimally Invasive Cardiac Surgery Technologies, 2006
Exhibit 3-2: Comparison of Beating Heart CABG Surgery Techniques
Exhibit 3-3: Benefits and Limitations of OPCAB
Exhibit 3-4: U.S. Beating Heart CABG Procedures, 2004-2010
Exhibit 3-5: Selected Cardiac Stabilizers, Positioners and Retractor Systems, 2006
Exhibit 3-6: Beating Heart Surgical Instruments' Platypus Reusable Stabilizer
Exhibit 3-7: Boston Scientific Beating Heart Products
Exhibit 3-8: Chase Medical TRIPOD Stabilizer System
Exhibit 3-9: CoroNeo Cor-Vasc System
Exhibit 3-10: ESTECH Stabilizer and Positioner Products
Exhibit 3-11: CardioVations Embrace Stabilization System
Exhibit 3-12: Medtronic Beating Heart Surgery Products
Exhibit 3-13: Teleflex Medical Beating Heart Surgery Products
Exhibit 3-14: Tentacles Cardiac Positioner
Exhibit 3-15: U.S. Beating Heart Product Market, 2004-2010
Exhibit 3-16: U.S. Beating Heart Products, Supplier Shares, 2004-2005
Exhibit 3-17: Selected Anastomosis Assist Devices, 2006
Exhibit 3-18: Boston Scientific Heartstring II Proximal Seal System
Exhibit 3-19: Selected Studies of the Heartstring Proximal Seal System
Exhibit 3-20: Novare Surgical Systems Enclose II Anastomosis Assist Device
Exhibit 3-21: Selected Clinical Studies of the Enclose System
Exhibit 3-22: U.S. Coronary Anastomoses, 2004-2010
Exhibit 3-23: U.S. Anastomosis Assist Device Market, 2004-2010
Exhibit 3-24: Anastomosis Assist Devices, Supplier Shares, 2004-2005
Exhibit 3-25: Major Design Approaches for Automated Anastomosis Devices
Exhibit 3-26: Selected Automated Anastomosis Devices, 2006
Exhibit 3-27: Cardica's Automated Anastomosis Devices
Exhibit 3-28: Clinical Results with Cardica's PAS-Port Proximal Anastomosis System
Exhibit 3-29: iiTech's S² Anastomotic System
Exhibit 3-30: Medtronic's U-Clip and SPYDER Devices
Exhibit 3-31: Selected Clinical Studies of the U-Clip Device
Exhibit 3-32: Rintek CABG Instrument
Exhibit 3-33: Deployment of Rintek CABG Instrument
Exhibit 3-34: U.S. Market for Automated Anastomosis Devices, 2004-2010
Exhibit 3-35: Advantages and Limitations of Intracoronary Shunting for Beating Heart CABG Surgery
Exhibit 3-36: Selected Clinical Studies of Intracoronary Shunts
Exhibit 3-37: Selected Intracoronary Shunt Product and Suppliers, 2006
Exhibit 3-38: Comparison of CABG Graft Sources
Exhibit 3-39: Selected Studies of Radial Artery Harvesting
Exhibit 3-40: Selected Studies of GEA Grafting for Revascularization
Exhibit 3-41: Selected Studies of ITA Grafts for Revascularization
Exhibit 3-42: Selected Artificial Coronary Graft Programs, 2006
Exhibit 3-43: Advantages and Limitations of Minimally Invasive Vein Harvesting
Exhibit 3-44: Selected Minimally Invasive Vessel Harvesting Systems, 2006
Exhibit 3-45: Boston Scientific's VasoView EVH Systems
Exhibit 3-46: Datascope's ClearGlide EVH System
Exhibit 3-47: Clinical Use of the Harmonic Scalpel in Minimally Invasive Vessel Harvesting
Exhibit 3-48: Teleflex Medical's SaphLITE/RadLITE System with Genzarm
Exhibit 3-49: Terumo's VirtuoSaph Endoscopic Vein Harvesting System
Exhibit 3-50: Tyco Healthcare's Mini-Harvest and ENDOsaph Systems
Exhibit 3-51: U.S. Market for Minimally Invasive Vessel Harvesting Systems, 2004-2010
Exhibit 3-52: Minimally Invasive Vein Harvesting Systems, Supplier Shares, 2005
4.0 ADJUNCTIVE TECHNOLOGIES
4.1 Robotic Systems
4.1.1 Background
4.1.2 Technology
4.1.2.1 Automated Mechanical Assist Devices
4.1.2.2 Telemanipulators
4.1.2.3 Autonomous Robots
4.1.3 Applications in Cardiac Surgery
4.1.4 Regulatory Issues
4.1.5 Reimbursement
4.1.6 Products
4.1.6.1 Armstrong Healthcare Limited
4.1.6.1.1 EndoAssist
4.1.6.1.2 PathFinder
4.1.6.2 Enhanced Medical Systems
4.1.6.3 Hansen Medical
4.1.6.4 Intuitive Surgical
4.1.6.4.1 daVinci Surgical System
4.1.6.4.2 AESOP
4.1.6.5 MedSys
4.1.6.6 Micro Dexterity Systems
4.1.7 Procedure Trend
4.1.8 Market Analysis
4.2 Advanced Visualization Systems
4.2.1 Technology
4.2.2 Requirements for Success.
4.2.3 Products and Suppliers
4.2.3.1 Estech
4.2.3.2 InnerOptic Technology
4.2.3.3 Medisecur AG
4.2.3.4 Microvision
4.2.3.5 Olympus Optical Company
4.2.3.6 Schoelly Fiberoptik GmbH (Intuitive Surgical)
4.2.3.7 Karl Storz Endoscopy
4.2.3.8 VisionSense
4.2.3.9 Viking Systems
4.2.3.10 VRex
4.2.4 Market Analysis
4.3 Endoscopic Tools
4.3.1 Intuitive Surgical (Endo-ACAB)
4.3.2 Johnson & Johnson CardioVations
4.3.2.1 Products
4.3.2.2 Procedure
4.3.2.2.1 Heartport Endoscopic CABG
4.3.2.2.2 Robotically-Assisted TECAB
4.3.2.3 Clinical Experience
4.3.2.4 Hybrid Revascularization
4.3.3 Market Analysis
Exhibit 4-1: Types of Surgical Robots
Exhibit 4-2: Selected Robotic Systems with Potential Application to Cardiac Surgery
Exhibit 4-3: Armstrong Healthcare EndoAssist and PathFinder
Exhibit 4-4: Enhanced Medical Systems' HeartLander System
Exhibit 4-5: Hansen Medical Sensei Robotic Catheter System
Exhibit 4-6: Intuitive Surgical daVinci System
Exhibit 4-7: daVinci Surgical System U.S. Installed Base
Exhibit 4-8: Intuitive Surgical AESOP 3000 System
Exhibit 4-9: MedSys LapMan Robotic Endoscope Positioner
Exhibit 4-10: Robotic-Assisted Beating Heart Cardiac Surgery, U.S. Equipment and Procedure Forecasts, 2004-2010
Exhibit 4-11: Cardiac Robotic Systems, Market Forecast, 2004-2010
Exhibit 4-12: Methods of Achieving Three-Dimensional Endoscopic Visualization
Exhibit 4-13: Selected Advanced Visualization Systems, 2006
Exhibit 4-14: InnerOptic 3D Laparoscope System and Head-Mounted Display
Exhibit 4-15: Viking Systems’ EndoSite 3Di Digital Vision System
Exhibit 4-16: Stand-Alone Advanced Visualization Systems, Market Forecast, 2004-2010
Exhibit 4-17: Suggested Anastomosis Technique for Beating Heart TECAB
Exhibit 4-18: Endoscopic CABG Surgery, Procedure and Market Forecast, 2004-2010
5.0 CARDIAC SURGICAL SEALANTS
5.1 Surgical Sealant Design Criteria
5.2 Types of Surgical Sealants
5.3 Biological Hemostatic Agents
5.3.1 Fibrin Sealants
5.3.1.1 Mechanism of Action
5.3.1.2 Development History and Impact
5.3.1.3 Clinical Applications
5.3.1.4 Commercial versus Non-Commercial Products
5.3.1.5 Commercial Fibrin Sealant Products
5.3.1.5.1 Baxter Bioscience (Tisseel)
5.3.1.5.2 Haemacure Corporation (Hemaseel)
5.3.1.5.3 Omrix Biopharmaceuticals/Ethicon (Crosseal, Evicel)
5.3.2 Hemostatic Matrices
5.3.2.1 Baxter Bioscience (FloSeal)
5.3.2.2 Ethicon (SurgiFlo)
5.3.2.3 Orthovita/Angiotech Pharmaceuticals
5.3.3 Autologous Platelet Products.
5.3.3.1 Biomet (Gravitational Platelet Separation System)
5.3.3.2 Harvest Technologies
5.3.3.3 ThermoGenesis
5.3.3.4 Vivolution A/S
5.4 Recombinant Surgical Hemostasis Products
5.4.1 Pharming Group NV
5.4.2 ZymoGenetics
5.5 Synthetic Sealants
5.5.1 Angiotech Pharmaceuticals/Baxter
5.5.2 CryoLife
5.5.3 Johnson & Johnson/Closure Medical Corporation
5.5.4 Tissuemed
5.6 Allogenic Products
5.7 Viral Screening and Inactivation of Blood Products
5.7.1 New Risks
5.7.2 Viral Inactivation and Removal Methods
5.8 Market Analysis
5.9 Supplier Shares
Exhibit 5-1: Design Criteria for Ideal Surgical Sealant
Exhibit 5-2: Types of Surgical Sealants
Exhibit 5-3: Selected Biologic Fibrin Sealants, 2006
Exhibit 5-4: Selected Hemostatic Matrices, 2006
Exhibit 5-5: Selected Technologies Producing Autologous Platelet Gels and Fibrin Sealant, 2006
Exhibit 5-6: Selected Recombinant Surgical Hemostasis Programs, 2006
Exhibit 5-7: Selected Synthetic Sealants, 2006
Exhibit 5-8: Current and Emerging Viral Inactivation and Removal Technologies
Exhibit 5-9: Cardiac Surgical Sealants, Market Forecast by Type, 2004-2010
Exhibit 5-10: Cardiopulmonary Bypass Surgical Sealants, Supplier Shares, 2005
6.0 TRANSMYOCARDIAL REVASCULARIZATION
6.1 Clinical Background
6.2 TMR Technique
6.3 Clinical Results
6.3.1 Long-Term Results
6.3.2 Adjunctive Use with CABG
6.3.3 Endoscopic and Robotically Assisted TMR
6.3.4 Cardiac Allograft Vasculopathy
6.4 Proposed Mechanisms of Action
6.4.1 Channel-Mediated Perfusion
6.4.2 Angiogenesis
6.4.3 Myocardial Denervation
6.4.4 Placebo Effect
6.5 Products and Suppliers
6.5.1 CardioGenesis
6.5.1.1 Technology
6.5.1.2 Clinical Use
6.5.1.3 PMC
6.5.2 Photomedex
6.5.2.1 Litigation
6.5.2.2 Current Status
6.5.3 PLC Medical Systems
6.5.3.1 Technology
6.5.3.2 Clinical Use
6.5.3.3 Relationship with Edwards Lifesciences
6.6 Reimbursement
6.7 Market Analysis
6.7.1 Procedure Forecast
6.7.2 Market Forecast
6.7.3 Competitive Analysis
Exhibit 6-1: Standard Angina Classification
Exhibit 6-2: Characteristics of "No Option" Angina Patients
Exhibit 6-3: Comparison of TMR and PMC
Exhibit 6-4: TMR Practice Guidelines, Recommendations
Exhibit 6-5: Summary Results of Randomized Clinical Trials for Sole Therapy TMR
Exhibit 6-6: Selected Clinical Studies of Concomitant TMR with CABG
Exhibit 6-7: Transmyocardial Revascularization: Potential Mechanisms of Action
Exhibit 6-8: Overview of Selected Studies Combining TMR with Gene or Cell Therapy
Exhibit 6-9: Selected Transmyocardial Laser Revascularization Programs
Exhibit 6-10: CardioGenesis TMR 2000 Holmium:YAG Laser TMR System
Exhibit 6-11: Cardiogenesis TMR Plus Platform
Exhibit 6-12: PLC Medical Systems' Heart Laser 2 TMR System
Exhibit 6-13: Transmyocardial Revascularization, Procedure Forecast, 2004-2010
Exhibit 6-14: Transmyocardial Revascularization, Market Forecast, 2004-2010
Exhibit 6-15: Transmyocardial Revascularization, Supplier Shares, 2005
7.0 COMPANY PROFILES
7.1 Baxter International, Inc
7.2 Cardica, Inc
7.3 Chase Medical, Inc
7.4 CryoLife, Inc
7.5 Edwards Lifesciences Corporation
7.6 Endoscopic Technologies, Inc
7.7 Getinge AG
7.8 Guidant Corporation (Boston Scientific)
7.9 Intuitive Surgical, Inc
7.10 Johnson & Johnson
7.11 Medtronic, Inc
7.12 Pall Corporation
7.13 Sorin Group
7.14 Terumo Corporation