The TwinFlo™ Catheter is designed to treat and protect the ischemic brain by providing rapid and selective cerebral hypothermia. It will offer a major advancement to the technology and treatment paradigms available to patients facing serious neurological damage and death. The unique design of TwinFlo™ results in more rapid and deeper localized cooling of the brain, while maintaining the remainder of the body at normal temperature (selective hypothermia). This differs from other hypothermia treatments that are unable to bring the brain to a sufficiently low temperature without significant total-body cooling and detrimental systemic effects. The design also permits selective drug and/or device delivery concurrent with the hypothermia treatment.